CARD14 Antibody

The protein encoded by the CARD14 gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class ofproteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions ofthe plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying acharacteristic caspase-associated recruitment domain (CARD). This protein shares a similar domain structure withCARD11 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein knownto function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this proteinactivated NF-kappaB and induced the phosphorylation of BCL10. Two alternatively spliced variants of this gene encodingdistinct isoforms have been reported. (provided by RefSeq)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

We have publications tested in 1 confirmed species: Human.

We have publications tested in 2 applications: IF/IHC, IHC-P.

Showing Publications 1 - 3 of 3.

Publications using NBP1-88598	Applications	Species
Peled A, Sarig O, Sun G et al. Loss-of-function mutations in CARD14 are associated with a severe variant of atopic dermatitis. J. Allergy Clin. Immunol. 2018-09-21 [PMID: 30248356] (IHC-P, Human)	IHC-P	Human
Eytan O, Qiaoli L, Nousbeck J et al. Increased epidermal expression and absence of mutations in CARD14 in a series of sporadic PRP patients. Br J Dermatol 2013-12-20 [PMID: 24359224] (IHC-P, Human)	IHC-P	Human
Fuchs-Telem D, Sarig O, van Steensel MA et al. Familial Pityriasis Rubra Pilaris Is Caused by Mutations in CARD14 Am J Hum Genet 2012-06-13 [PMID: 22703878] (IF/IHC, Human)	IF/IHC	Human

Array NBP1-88598

• CARD14 Antibodies
• CARD14 Lysate
• CARD14 Protein