Slug Products

Description

SLUG encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects.

Bioinformatics

Entrez	20583 Mouse 6591 Human
Uniprot	AAH14890 Human NM_003068 Human NP_003059 Human NP_003059.1 Human O43623 Human
Product By Gene ID	6591
Alternate Names	MGC10182 Neural crest transcription factor Slug Protein snail homolog 2 slug homolog, zinc finger protein (chicken) SLUGH SLUGzinc finger protein snail 2 snail homolog 2 (Drosophila) WS2D zinc finger protein SNAI2

Diseases related to Slug

Discover more about diseases related to Slug.

Malignant Neoplasms
Neoplasms
Cell Invasion
Neoplasm Metastasis
Carcinoma
Malignant Neoplasm Of Breast
Neoplasm Invasiveness
Crest Syndrome
Cell Transformation, Neoplastic
Mammary Neoplasms
Tissue Adhesions
Malignant Paraganglionic Neoplasm
Carcinogenesis
Waardenburg Syndrome
Malignant Squamous Cell Neoplasm
Malignant Neoplasm Of Prostate
Malignant Tumor Of Colon
Tumor Progression

Pathways for Slug

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Cell Migration
Epithelial To Mesenchymal Transition
Cell Proliferation
Cell Cycle
Rna Interference
Wound Healing
Cell Motility
Gastrulation
Cell Adhesion
Cell-cell Adhesion
Aging
Pigmentation
Methylation
Dna Methylation
Delamination
Pathogenesis
Gene Silencing
Cell Fate Determination
Localization
Senescence

Research Areas for Slug

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Neuronal Cell Markers
Neuronal Stem Cell Markers
Phospho-Specific

PTMs for Slug

Learn more about PTMs related to Slug.

Phosphorylation
Methylation
Demethylation
Cleavage

Bioinformatics Tool for Slug

Discover related pathways, diseases and genes to Slug. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 

Related Slug Blog Posts

Check out the latest blog posts on Slug.

Epithelial-Mesenchymal Transition (EMT) Markers Epithelial-Mesenchymal Transition (EMT) is the trans-differentiation of stationary epithelial cells into motile mesenchymal cells. During EMT, epithelial cells lose their junctions and apical-basal polarity, reorganize their cytoskeleton, undergo a...    Read more.

Read more.

CD63: is it pro-metastatic or anti-metastatic? CD63 is a type II membrane protein belonging to tetraspanin superfamily and it play key roles in the activation of several cellular signaling cascades along with acting as TIMP1 receptor. It is expressed by activated platelets, monocytes,...    Read more.

Read more Slug related blogs.