MCAM/CD146 Products

MCAM/CD146 Antibody [Unconjug ...
MCAM/CD146 Antibody [Unconjugated]
Species: Hu
Applications: WB, Simple Western, IHC, ICC/IF
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
Antibody Pairs
MCAM/CD146 Antibody Pair [HRP ...
MCAM/CD146 Antibody Pair [HRP]
Species: Hu
Applications: S-ELISA
Host: Monoclonal
Conjugate Catalog # Availability Size Price
MCAM/CD146 Overexpression Lys ...
MCAM/CD146 Overexpression Lysate (...
Species: Hu
Applications: WB
Recombinant Human MCAM/CD146 ...
Recombinant Human MCAM/CD146 Fc Ch...
Species: Hu
Applications: Bioactivity
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Recombinant Mouse MCAM/CD146 ...
Recombinant Mouse MCAM/CD146 Fc Ch...
Species: Mu
Applications: Bioactivity
Formulation Catalog # Availability Price  
MCAM/CD146 Recombinant Protei ...
MCAM/CD146 Recombinant Protein Ant...
Species: Hu
Applications: AC


CD146 belongs to the immunoglobulin supergene family with five immunoglobulin like domains (V-V-C2-C2-C2), a transmembrane region and a 63 residue cytoplasmic tail. The protein is a membrane glycoprotein that functions as a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions. CD146 has a molecular size of 130 kDa in its reduced form (118 kDa unreduced), and N linked glycosylation accounts for fifty percent of the apparent molecular weight. In some cells the molecule carries a sulfate 3 glucuronyl moiety. Expression of the molecule was shown in a relatively limited spectrum of normal human tissues (endothelium, smooth muscle, and subpopulations of activated T cells) and malignant neoplasm (melanoma and breast carcinoma). The lineage specific expression pattern of CD146 can be useful in the differential diagnosis of certain lesions including melanomas and various types of gestational trophoblastic lesions. CD146 expression can promote tumor progression in human melanoma, through enhanced interaction between melanoma cells and endothelial cells. However, in breast carcinoma, CD146 may act as a tumor suppressor. Over expression of CD146 in breast carcinoma cells results in a more cohesive cell growth and in the formation of smaller tumors in nude mice. During implantation and placentation, CD146 is expressed by the intermediate trophoblast in the placental site and binds to its putative receptor in uterine smooth muscle cells thus limiting trophoblastic invasion in the myometrium. Monoclonal antibody specific for CD146 is an important tool for the identification and isolation of cells expressing CD146.


Entrez Human
Uniprot Human
Product By Gene ID 4162
Alternate Names
  • Melanoma-associated antigen MUC18
  • CD146 antigen
  • Melanoma-associated antigen A32
  • melanoma adhesion molecule
  • Cell surface glycoprotein P1H12
  • cell surface glycoprotein MUC18
  • CD146
  • MUC18Gicerin
  • melanoma cell adhesion moleculeS-endo 1 endothelial-associated antigen

Research Areas for MCAM/CD146

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Mesenchymal Stem Cell Markers
Stem Cell Markers

PTMs for MCAM/CD146

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Bioinformatics Tool for MCAM/CD146

Discover related pathways, diseases and genes to MCAM/CD146. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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