MCAM/CD146 Products

Description

CD146 belongs to the immunoglobulin supergene family with five immunoglobulin like domains (V-V-C2-C2-C2), a transmembrane region and a 63 residue cytoplasmic tail. The protein is a membrane glycoprotein that functions as a Ca2+ independent cell adhesion molecule involved in heterophilic cell to cell interactions. CD146 has a molecular size of 130 kDa in its reduced form (118 kDa unreduced), and N linked glycosylation accounts for fifty percent of the apparent molecular weight. In some cells the molecule carries a sulfate 3 glucuronyl moiety. Expression of the molecule was shown in a relatively limited spectrum of normal human tissues (endothelium, smooth muscle, and subpopulations of activated T cells) and malignant neoplasm (melanoma and breast carcinoma). The lineage specific expression pattern of CD146 can be useful in the differential diagnosis of certain lesions including melanomas and various types of gestational trophoblastic lesions. CD146 expression can promote tumor progression in human melanoma, through enhanced interaction between melanoma cells and endothelial cells. However, in breast carcinoma, CD146 may act as a tumor suppressor. Over expression of CD146 in breast carcinoma cells results in a more cohesive cell growth and in the formation of smaller tumors in nude mice. During implantation and placentation, CD146 is expressed by the intermediate trophoblast in the placental site and binds to its putative receptor in uterine smooth muscle cells thus limiting trophoblastic invasion in the myometrium. Monoclonal antibody specific for CD146 is an important tool for the identification and isolation of cells expressing CD146.

Bioinformatics

Entrez	4162 Human 78967 Rat 84004 Mouse
Uniprot	AAA20824 Human AAH56418 Human NP_006491.2 Human P43121 Human
Product By Gene ID	4162
Alternate Names	CD146 antigen CD146 cell surface glycoprotein MUC18 Cell surface glycoprotein P1H12 melanoma adhesion molecule melanoma cell adhesion moleculeS-endo 1 endothelial-associated antigen Melanoma-associated antigen A32 Melanoma-associated antigen MUC18 MUC18Gicerin

Research Areas for MCAM/CD146

Find related products by research area and learn more about each of the different research areas below.

Cancer
Mesenchymal Stem Cell Markers
Phospho-Specific
Stem Cell Markers