ZAK Antibody [Alexa Fluor™ Plus 594]

• Reactivity: Hu
• Applications: WB, IP
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Alexa Fluor Plus 594

ZAK Antibody [Alexa Fluor™ Plus 594] Summary

• Immunogen: The immunogen recognized by this antibody maps to a region between residue 700 and 750 of human sterile alpha motif and leucine zipper containing kinase AZK using the numbering given in entry NP_057737.2 (GeneID 51776).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ZAK
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunoprecipitation
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Notes

This product is provided under an intellectual property license from Life Technologies Corporation. The transfer of this product is conditioned on the buyer using the purchased product solely in research conducted by the buyer, excluding contract research or any fee for service research, and the buyer must not (1) use this product or its components for (a) diagnostic, therapeutic or prophylactic purposes; (b) testing, analysis or screening services, or information in return for compensation on a per-test basis; or (c) manufacturing or quality assurance or quality control, and/or (2) sell or transfer this product or its components for resale, whether or not resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5781 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@thermofisher.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for ZAK Antibody [Alexa Fluor™ Plus 594]

• AZK
• EC 2.7.11
• EC 2.7.11.25
• HCCS-4
• Human cervical cancer suppressor gene 4 protein
• Leucine zipper- and sterile alpha motif-containing kinase
• mitogen-activated protein kinase kinase kinase MLT
• mixed lineage kinase 7
• mixed lineage kinase with a leucine zipper and a sterile alpha motif
• mixed lineage kinase-related kinase MRK-beta
• Mixed lineage kinase-related kinase
• MLK7
• mlklak
• MLK-like mitogen-activated protein triple kinase
• MLK-related kinase
• MLT
• MLTK
• MRKcervical cancer suppressor gene 4 protein
• pk
• protein kinase
• sterile alpha motif and leucine zipper containing kinase AZK
• Sterile alpha motif- and leucine zipper-containing kinase AZK

Background

ZAK is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: ZAK