VPS36 Antibody

Product Discontinued

VPS36 Antibody Summary

• Immunogen: A synthetic peptide from the internal part of mouse Vacuolar protein-sorting-associated protein 36 (VPS36) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat.
• Localization: subcellular location: cytoplasm. late endosome. nucleus. notel colocalizes with ubiquitinated proteins on late endosomes.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: VPS36
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:300-1:2000
  • Western Blot 1:300-1:2000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Whole antisera
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Unpurified
• Reconstitution Instructions: Reconstitute in 100 ul of sterile water. Centrifuge to remove any insoluble material. Glycerol may be added (1:1) for additional stability.

Alternate Names for VPS36 Antibody

• C13orf9
• CGI-145
• DKFZp781E0871
• Eap45
• EAP45chromosome 13 open reading frame 9
• ELL-associated protein of 45 kDa
• ELL-associated protein, 45 kDa
• ESCRT-II complex subunit VPS36
• vacuolar protein sorting 36 homolog (S. cerevisiae)
• vacuolar protein sorting 36 homolog (yeast)
• vacuolar protein-sorting-associated protein 36

Background

Component of the escrt-ii complex, which is required for multivesicular bodies (mvbs) formation and sorting of endosomal cargo proteins into mvbs. the mvb pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. the escrt-ii complex is probably involved in the recruitment of the escrt-iii complex. its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by escrt complexes. the escrt-ii complex may also play a role in transcription regulation, possibly via its interaction with ell.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: VPS36
• Entrez:
  • 70160(Mouse)
  • 290851(Rat)
• Uniprot:
  • Q91XD6(Mouse)