VPS24 Antibody

Product Discontinued

VPS24 Antibody Summary

• Immunogen: A synthetic peptide from the n-terminal of human CHMP3 (Charged multivesicular body protein 3, Vacuolar protein sorting associated protein 24, VPS24) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse.
• Specificity: Appears to be specific for CHMP3.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Gene: CHMP3
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
  • Western Blot 1:100-1:2000

Reactivity Notes

Mouse, rat, human. Other species not yet tested.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (1x)
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: IgG purified
• Reconstitution Instructions: Reconstitute in 500 ul of sterile water. Centrifuge to remove any insoluble material. Glycerol may be added (1:1) for additional stability.

Alternate Names for VPS24 Antibody

• CGI-149
• CHMP325.1 protein
• Chromatin-modifying protein 3
• hVps24
• member 3,25.1
• NEDFFLJ38114
• vacuolar protein sorting 24 (yeast)
• vacuolar protein sorting 24 homolog (S. cerevisiae)

Background

Component of the escrt-iii complex, which is required for multivesicular bodies (mvbs) formation and sorting of endosomal cargo proteins into mvbs. the mvb pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. the escrt-iii complex is probably involved in the concentration of mvb cargo. required for sorting/trafficking of egf receptor. in case of infection, the hiv-1 virus takes advantage of the escrt-iii complex for budding and exocytic cargos of viral proteins.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CHMP3
• Entrez:
  • 51652(Human)