VHR/DUSP3 Antibody [DyLight 650]

• Reactivity: Hu
• Applications: WB, ELISA, IP
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: DyLight 650

VHR/DUSP3 Antibody [DyLight 650] Summary

• Immunogen: Produced in rabbits immunized with purified, recombinant Human VHR/DUSP3 (Accession#: P51452; Met1-Pro185)
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: DUSP3
• Purity: Antigen and protein A Affinity-purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunoprecipitation
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Antigen and protein A Affinity-purified

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for VHR/DUSP3 Antibody [DyLight 650]

• dual specificity phosphatase 3
• dual specificity protein phosphatase 3
• Dual specificity protein phosphatase VHR
• DUSP3
• EC 3.1.3.16
• EC 3.1.3.48
• Vaccinia H1-related phosphatase
• vaccinia virus phosphatase VH1-related
• VHR
• VHRserine/threonine specific protein phosphatase

Background

DUSP3 is encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: DUSP3