VHR/DUSP3 Products

Description

DUSP3 is encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.

Bioinformatics

Entrez	1845 Human
Uniprot	AAH02682 Human AAH35701 Human NM_004090 Human NP_004081 Human NP_004081.1 Human P51452 Human
Product By Gene ID	1845
Alternate Names	dual specificity phosphatase 3 dual specificity protein phosphatase 3 Dual specificity protein phosphatase VHR EC 3.1.3.16 EC 3.1.3.48 Vaccinia H1-related phosphatase vaccinia virus phosphatase VH1-related VHRserine/threonine specific protein phosphatase

Research Areas for VHR/DUSP3

Find related products by research area and learn more about each of the different research areas below.

Cancer
Protein Phosphatase