VHR/DUSP3 Products

Antibodies
VHR/DUSP3 Antibody (237020)
VHR/DUSP3 Antibody (237020)
MAB1654
Species: Hu, Mu, Rt
Applications: WB
Host: Mouse Monoclonal
VHR/DUSP3 Antibody (237018)
VHR/DUSP3 Antibody (237018)
MAB16541
Species: Hu
Applications: IHC
Host: Mouse Monoclonal
VHR/DUSP3 Antibody
VHR/DUSP3 Antibody
NBP1-33099
Species: Hu, Mu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
VHR/DUSP3 Overexpression Lysa ...
VHR/DUSP3 Overexpression Lysate (D...
H00001845-T01
Species: Hu
Applications: WB
VHR/DUSP3 Overexpression Lysa ...
VHR/DUSP3 Overexpression Lysate (N...
NBL1-10053
Applications: WB
Proteins
Recombinant Human VHR/DUSP3 P ...
Recombinant Human VHR/DUSP3 Protein
H00001845-P02
Species: Hu
Applications: WB, ELISA, PA
VHR/DUSP3 Recombinant Protein ...
VHR/DUSP3 Recombinant Protein Antigen
NBP2-57387PEP
Species: Hu
Applications: AC
Recombinant Human VHR/DUSP3 P ...
Recombinant Human VHR/DUSP3 Protein
NBP1-72478
Species: Hu
Applications: Func, PAGE
RNAi
VHR/DUSP3 RNAi
VHR/DUSP3 RNAi
H00001845-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

DUSP3 is encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 1845
Alternate Names
  • Vaccinia H1-related phosphatase
  • EC 3.1.3.48
  • Dual specificity protein phosphatase VHR
  • EC 3.1.3.16
  • vaccinia virus phosphatase VH1-related
  • VHRserine/threonine specific protein phosphatase
  • dual specificity protein phosphatase 3
  • dual specificity phosphatase 3

Research Areas for VHR/DUSP3

Find related products by research area and learn more about each of the different research areas below.

Cancer
Protein Phosphatase

PTMs for VHR/DUSP3

Learn more about PTMs related to VHR/DUSP3.

Phosphorylation
Dephosphorylation
Reduction
Cleavage
Oxidation

Bioinformatics Tool for VHR/DUSP3

Discover related pathways, diseases and genes to VHR/DUSP3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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