VHR/DUSP3 Antibody

Images

 
Western Blot: VHR/DUSP3 Antibody [NBP1-33099] - Sample (30 ug of whole cell lysate) A: 293T 12% SDS PAGE; antibody diluted at 1:1000.
Immunohistochemistry-Paraffin: VHR/DUSP3 Antibody [NBP1-33099] - Paraffin-embedded N87 xenograft, using antibody at 1:500 dilution.
Western Blot: VHR/DUSP3 Antibody [NBP1-33099] - Sample (50 ug of whole cell lysate) A: mouse stomach 12% SDS PAGE; antibody diluted at 1:1000.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.58 mg/ml

Order Details

VHR/DUSP3 Antibody Summary

Immunogen
Full length human DUSP3 Recombinant protein.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
DUSP3
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
  • Immunohistochemistry 10 - 1:500
  • Immunohistochemistry-Paraffin 1:100-1:1000

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
Preservative
0.01% Thimerosal
Concentration
0.58 mg/ml
Purity
Immunogen affinity purified

Alternate Names for VHR/DUSP3 Antibody

  • dual specificity phosphatase 3
  • dual specificity protein phosphatase 3
  • Dual specificity protein phosphatase VHR
  • DUSP3
  • EC 3.1.3.16
  • EC 3.1.3.48
  • Vaccinia H1-related phosphatase
  • vaccinia virus phosphatase VH1-related
  • VHR
  • VHRserine/threonine specific protein phosphatase

Background

The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol DUSP3
Entrez