Recombinant Human VEGF-D Protein Summary
Recombinant protein for Human VEGF-D
Amino Acid Sequence:(O43915)
| Protein/Peptide Type
>95%, by SDS-PAGE
Packaging, Storage & Formulations
Store at -20 to -80C. Avoid freeze-thaw cycles.
Lyophilized without additives
>95%, by SDS-PAGE
Reconstitute in dH2O to a concentration of 0.1-1.0 mg/ml. The solution should be stored at -70C.
Alternate Names for Recombinant Human VEGF-D Protein
- c-fos induced growth factor (vascular endothelial growth factor D)
- vascular endothelial growth factor D
- VEGF-DVEGFDc-Fos-induced growth factor
VEGF-D is most closely related to VEGF-C by virtue of the presence of N- and C-terminal extensions that are not found in other VEGF family members. In adult human tissues, VEGF-D mRNA is most abundant in heart, lung, skeletal muscle, colon, and small intestine. Analyses of VEGF-D receptor specificity revealed that VEGF-D is a ligand for both VEGF receptors (VEGFRs) VEGFR-2 (Flk1) and VEGFR-3 (Flt4) and can activate these receptors. However, VEGF-D does not bind to VEGFR-1. Expression of a truncated derivative of VEGF-D demonstrated that the receptor-binding capacities reside in the portion of the molecule that is most closely related in primary structure to other VEGF family members and that corresponds to the mature form of VEGF-C. In addition, VEGF-D is a mitogen for endothelial cells. Recombinant VEGF-D was expressed based on sequence from Genebank Accession# D89630, 20-354 aa.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
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