ULBP-1 Antibody (MM0592-10K10) - Azide and BSA Free

Product Discontinued

ULBP-1 Antibody (MM0592-10K10) - Azide and BSA Free Summary

• Immunogen: Human recombinant ULBP-1
• Isotype: IgG2
• Clonality: Monoclonal
• Host: Mouse
• Gene: ULBP1
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Block/Neutralize
  • CyTOF-ready
  • Flow Cytometry 1:50-1:100
• Application Notes: This antibody has been used to neutralize ligand/receptor interaction. This antibody is CyTOF ready.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Lyophilized from a 0.2 um filtered solution in PBS. 0.025 mg size is provided in liquid form, PBS
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Protein G purified
• Reconstitution Instructions: Reconstitute with sterilized PBS to a final concentration of 0.5 mg/ml.

Alternate Names for ULBP-1 Antibody (MM0592-10K10) - Azide and BSA Free

• ALCAN-beta
• MULT-1
• N2DL1
• N2DL-1
• NKG2D ligand 1
• NKG2DL
• NKG2DL1
• RAET1I
• RAET1Ialcan-beta
• Retinoic acid early transcript 1I
• UL16 binding protein 1
• UL16-binding protein 1
• ULBP1
• ULBP-1

Background

Ligand for the NKG2D receptor, together with at least ULBP2 and ULBP3. ULBPs activate multiple signalingpathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands toNKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transductionpathway. In CMV infected cells, interacts with soluble CMV glycoprotein UL16. The interaction with UL16 blocked theinteraction with the NKG2D receptor, providing a mechanism by which CMV infected cells might escape the immune system.UL16 also causes ULBP1 to be retained in the ER and cis-Golgi apparatus so that it does not reach the cell surface

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for ULBP-1 Antibody (NBP2-11986)(2)

Publications using NBP2-11986

• Calabrese DR, Tsao T, Magnen M Et al. NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes JCI Insight 2022-11-08 [PMID: 36346670] (FLOW, Human)
  
  Details:
  Citation using the Alexa Fluor 700 version of this antibody.
• Van der Meer JMR, de Jonge PKJD, van der Waart AB et al. CD34(+) progenitor-derived NK cell and gemcitabine combination therapy increases killing of ovarian cancer cells in NOD/SCID/IL2Rg(null) mice OncoImmunology 2021-10-07 [PMID: 34616589]

Bioinformatics

• Gene Symbol: ULBP1
• Uniprot:
  • Q9BZM6(Human)