ULBP-1 Antibody (237104) [Alexa Fluor® 647] Summary
BaF3 mouse pro-B cell line transfected with mouse ULBP‑1 /MULT-1
Detects mouse ULBP‑1 /MULT-1.
Test in a species/application not listed above to receive a full credit towards a future purchase.
- Flow Cytometry 0.25-1 ug/10^6 cells
Flow Cytometry: Please use 0.25-1 ug of conjugated antibody per 10e6 cells.
Packaging, Storage & Formulations
Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
0.09% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for ULBP-1 Antibody (237104) [Alexa Fluor® 647]
- NKG2D ligand 1
- Retinoic acid early transcript 1I
- UL16 binding protein 1
- UL16-binding protein 1
ULBP-1, also known as MULT-1 (mouse UL16-binding protein-like Transcript 1), is a 53 kDa, MHC Class I-like molecule that belongs to the mouse family of NKG2D ligands (1‑4). It is a type I transmembrane glycoprotein that is synthesized as a 334 amino acid (aa) precursor. It contains a 25 aa signal sequence, a 186 aa extracellular region, a 19 aa transmembrane segment and a 104 aa cytoplasmic tail (2). The extracellular region contains an alpha 1 and alpha 2 like domain with two intrachain disulfide bonds. ULBP-1 is distantly related to other human and mouse NKG2D ligands, and more distantly related to the MHC class I proteins (3). Unlike most NKG2D ligands, transcripts for ULBP-1 have been detected in a wide variety of mouse tissues and tumor cells lines (3). The receptor for ULBP-1 is NKG2D, a 35 kDa C-type lectin that is found on mouse NK cells, activated CD8+ T cells, epidermal gamma δ T cells, and activated macrophages (1, 5, 6, 7). Recombinant ULBP-1 protein binds to NKG2D with high affinity (KD = 6 nM) (2). Although an activating receptor, general cellular responses to NKG2D ligation depend upon the isoform of NKG2D and the cell type (5). Exposure to immobilized ULBP-1 or ULBP-1-transfected cells elicits IFN-gamma production by NK cells (3). Ectopic expression of ULBP-1 on the RMA mouse tumor cell line leads to tumor rejection in syngeneic mice (3).
- Raulet, D.H. (2003) Nat. Rev. Immunol. 3:781.
- Carayannopoulos, L. et al. (2002) J. Immunol. 169:4079.
- Diefenbach, A. et al. (2003) Eur. J. Immunol. 33:381.
- Krmpotic, A. et al. (2005) J. Exp. Med. 201:211.
- Diefenbach, A. et al. (2002) Nat. Immunol. 3:1142.
- Ho, E.L. et al. (1998) Proc. Natl. Acad. Sci. USA 95:6320.
- Carayannopoulos, L.N. et al. (2002) Eur. J. Immunol. 32:597.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
Customers Who Viewed This Item Also Viewed...
Applications: WB, Flow, CostimT, CyTOF-ready, Neut
Applications: Flow, Block, CyTOF-ready
Applications: WB, Flow, CyTOF-ready, ELISA(Cap), ELISA(Det), ELISA(Sta)
Applications: WB, Flow, IHC, CyTOF-ready
Applications: WB, Flow, IHC, AgAct, CyTOF-ready
Species: Mu, Rt
Applications: Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, Cell Depl, CyTOF-ready, InhibTFunc
Species: Hu, Eq, Pm
Applications: WB, IHC-P
Species: Hu, Pm
Applications: WB, ICC/IF, IHC, IHC-P
Applications: Flow, IHC
Applications: B/N, ELISA, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP, CyTOF-ready, Flow-IC
Applications: WB, Flow, CyTOF-ready, Neut
Applications: WB, ELISA, IHC-P
Publications for ULBP-1 Antibody (FAB2588R) (0)
There are no publications for ULBP-1 Antibody (FAB2588R).
By submitting your publication information earn gift cards and discounts for future purchases.
Reviews for ULBP-1 Antibody (FAB2588R) (0)
There are no reviews for ULBP-1 Antibody (FAB2588R).
By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
- Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
- Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
- 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen
Product General Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
FAQs for ULBP-1 Antibody (FAB2588R) (0)
Additional Array Products
Bioinformatics Tool for ULBP-1 Antibody (FAB2588R)
Discover related pathways, diseases and genes to ULBP-1 Antibody (FAB2588R). Need help?
Read the Bioinformatics Tool Guide
for instructions on using this tool.
Blogs on ULBP-1