UGT1A9 Antibody

Western Blot: UGT1A9 Antibody [H00054600-B01P] - Analysis of UGT1A9 expression in human liver.

Immunohistochemistry-Paraffin: UGT1A9 Antibody [H00054600-B01P] - Analysis of purified antibody to UGT1A9 on formalin-fixed paraffin-embedded human small Intestine. (antibody concentration 3 ug/ml)

Western Blot: UGT1A9 Antibody [H00054600-B01P] - Analysis of UGT1A9 expression in transfected 293T cell line by UGT1A9 polyclonal antibody. Lane 1: UGT1A9 transfected lysate(58.3 KDa). Lane 2: Non-transfected lysate.

• Reactivity: Hu, Mu
• Applications: WB, ELISA, IHC, IHC-P
• Clonality: Polyclonal
• Host: Mouse
• Conjugate: Unconjugated

UGT1A9 Antibody Summary

• Immunogen: UGT1A9 (NP_066307.1, 1 a.a. ~ 530 a.a) full-length human protein.MACTGWTSPLPLCVCLLLTCGFAEAGKLLVVPMDGSHWFTMRSVVEKLILRGHEVVVVMPEVSWQLGRSLNCTVKTYSTSYTLEDLDREFKAFAHAQWKAQVRSIYSLLMGSYNDIFDLFFSNCRSLFKDKKLVEYLKESSFDAVFLDPFDNCGLIVAKYFSLPSVVFARGILCHYLEEGAQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLLCHRFFKNALEIASEILQTPVTEYDLYSHTSIWLLRT
• Specificity: UGT1A9 - UDP glucuronosyltransferase 1 family, polypeptide A9,
• Isotype: IgG
• Clonality: Polyclonal
• Host: Mouse
• Gene: UGT1A9
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:500
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
• Application Notes: Antibody reactive against Recombinant Protein with GST tag on ELISA and Western Blot and also on transfected lysate in western blot. GST tag alone is used as a negative control. Has also been used for immunohistochemistry (paraffin).

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID: 23055538)

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: Protein A purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for UGT1A9 Antibody

• A12
• EC 2.4.1.17
• GNT1
• HLUGP4
• LUGP4
• polypeptide A9
• UDP glucuronosyltransferase 1 family, polypeptide A9
• UDP-glucuronosyltransferase 1-9
• UDP-glucuronosyltransferase 1A9
• UDP-glucuronosyltransferase 1-I
• UDPGT 1-9
• UDPGT
• UDPGT1-9
• UGT1
• UGT1*9
• UGT1.9
• UGT1-09
• UGT1-9
• UGT1A9
• UGT1AI
• UGT1I
• UGT-1I

Background

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenols. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for UGT1A9 Antibody (H00054600-B01P)(3)

Publications using H00054600-B01P

• Wang H, Bian T, Jin T et al. Association analysis of UGT1A genotype and haplotype with SN-38 glucuronidation in human livers. Pharmacogenomics. 2014 Apr 01 [PMID: 24897286]
• Hardwick RN, Ferreira DW, More VR et al. Altered UDP-Glucuronosyltransferase and Sulfotransferase Expression and Function during Progressive Stages of Human Nonalcoholic Fatty Liver Disease. Drug Metab Dispos. 2012 Dec 07 [PMID: 23223517]
• Wen X, Donepudi AC, Thomas PE et al. Regulation of hepatic phase II metabolism in pregnant mice. J Pharmacol Exp Ther. 2013 Jan [PMID: 23055538] (WB, Mouse)

Bioinformatics

• Gene Symbol: UGT1A9
• Entrez:
  • 54600(Human)
  • 394434(Mouse)
  • 396552(Rat)
• Uniprot:
  • NP_066307.1(Human)