TWEAK/TNFSF12 Antibody (189803) [DyLight 594]

• Reactivity: Mu
• Applications: ELISA, ELISA(Cap), ELISA(Det)
• Clone: 189803
• Clonality: Monoclonal
• Host: Rat
• Conjugate: DyLight 594

TWEAK/TNFSF12 Antibody (189803) [DyLight 594] Summary

• Immunogen: E. coli-derived recombinant mouse TWEAK/TNFSF12
  Arg105-His249
  Accession # O54907.2
• Specificity: Detects mouse TWEAK/TNFSF12 in ELISAs. In sandwich ELISAs, approximately 5% cross-reactivity with recombinant human TWEAK is observed and no cross-reactivity with recombinant mouse (rm) BAFF, rmFas Ligand, rmOX40, or rmTNF-alpha is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Gene: Tnfsf12
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • ELISA Capture (Matched Antibody Pair)
  • ELISA Detection (Matched Antibody Pair)
  • ELISA Standard (Matched Pair)
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for TWEAK/TNFSF12 Antibody (189803) [DyLight 594]

• APO3 ligand
• APO3LMGC20669
• DR3LGTWEAKAPO3/DR3 ligand
• MGC129581
• TNF-related weak inducer of apoptosis
• TNFSF12
• tumor necrosis factor (ligand) superfamily, member 12
• tumor necrosis factor ligand superfamily member 12
• TWEAK

Background

CD266 is a 14 kD transmembrane protein known as TWEAK receptor (TWEAK-R) or fibroblast growth factor inducible 14 (Fn14). It is member 12A of the tumor necrosis factor receptor superfamily (TNFRSF12A) expressed at low levels in a variety of tissues, such as heart, placenta, lung, muscle, and pancreas. TWEAK-R binds TWEAK (CD255) and interacts with the cytoplasmic proteins TRAF1, 2, and 3. The engagement of Fn14 can induce cell death and may play a role in inflammation, hepatocyte growth, and liver neoplasia. ITEM-4 antibody reacts with both mouse and human Fn14. It is useful for flow cytometric analysis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: Tnfsf12