TSSC3 Antibody (5E3)

Sandwich ELISA: TSSC3 Antibody (5E3) [H00007262-M01] - Detection limit for recombinant GST tagged PHLDA2 is approximately 0.3ng/ml as a capture antibody.

• Reactivity: Hu
• Applications: WB, ELISA, IHC
• Clone: 5E3
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated

TSSC3 Antibody (5E3) Summary

• Description: Quality control test: Antibody Reactive Against Recombinant Protein.
• Immunogen: PHLDA2 (NP_003302, 1 a.a. ~ 110 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MKSPDEVLREGELEKRSDSLFQLWKKKRGVLTSDRLSLFPASPRARPKELRFHSILKVDCVERTGKYVYFTIVTTDHKEIDFRCAGESCWNAAIALALIDFQNRRALQDF
• Specificity: PHLDA2 - pleckstrin homology-like domain, family A, member 2
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: PHLDA2
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry
  • Sandwich ELISA
  • Western Blot
• Application Notes: Antibody reactivity against Recombinant Protein with GST tag on ELISA and WB. GST tag alone is used as a negative control.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: In 1x PBS, pH 7.4
• Preservative: No Preservative
• Purity: IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for TSSC3 Antibody (5E3)

• Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein
• BWR1Cp17-Beckwith-Wiedemann region 1 C
• HLDA2BRW1C
• Imprinted in placenta and liver protein
• IPLp17-BWR1C
• pleckstrin homology-like domain family A member 2
• pleckstrin homology-like domain, family A, member 2
• TSSC3p17-Beckwith-Wiedemann region 1C
• tumor suppressing subchromosomal transferable fragment cDNA 3
• tumor suppressing subtransferable candidate 3
• Tumor-suppressing STF cDNA 3 protein
• Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein
• tumor-supressing STF cDNA 3

Background

This gene is one of several genes in the imprinted gene domain of 11p15.5 which is considered to be an important tumor suppressor gene region. Alterations in this region may be associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Studies of the mouse gene, however, which is also located in an imprinted gene domain, have shown that the product of this gene regulates placental growth.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TSSC3 Antibody (H00007262-M01)(1)

Publication using H00007262-M01

• Suzuki S, Shaw G, Kaneko-Ishino T et al. Characterisation of marsupial PHLDA2 reveals eutherian specific acquisition of imprinting. BMC Evol Biol. 2011-08-19 [PMID: 21854573]

Bioinformatics

• Gene Symbol: PHLDA2
• Entrez:
  • 7262(Human)
• OMIM:
  • 602131(Human)
• Uniprot:
  • NP_003302(Human)