TSPAN12 Antibody (921938) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 921938
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

TSPAN12 Antibody (921938) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human TSPAN12 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TSPAN12 Antibody (921938) [Alexa Fluor™ Plus 647]

• EVR5
• Leukemia-associated protein with a CXXC domain
• methylcytosine dioxygenase TET1
• NET2
• NET-2
• ten-eleven translocation-1
• tetraspanin-12
• TM4SF12
• TSPAN12

Background

TSPAN12 is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. They mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. TSPAN12 plays a central role in retinal vascularization by regulating norrin signal transduction. TSPAN12 acts in concert with norrin to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin and stimulate LEF/TCF-mediated transcriptional programs. Defects in TSPAN12 are the cause of vitreoretinopathy exudative type 5, a disorder of the retinal vasculature characterized by an abrupt cessation of growth of peripheral capillaries, leading to an avascular peripheral retina.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.