TREML1/TLT-1 Antibody

Western Blot: TREML1/TLT-1 Antibody [NBP1-45208] - (0.5ug/ml) Analysis of Human Bone Marrow lysate (RIPA buffer, 35ug total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence.

• Reactivity: Hu
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

TREML1/TLT-1 Antibody Summary

• Description: Novus Biologicals Goat TREML1/TLT-1 Antibody (NBP1-45208) is a polyclonal antibody validated for use in WB and ELISA. Anti-TREML1/TLT-1 Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Peptide with sequence CGPAQNPPNNQTPS corresponding to C-Terminus according to NP_835468.1.
• Epitope: C-Terminus
• Specificity: This antibody may cross-react with mouse TREML1 (GeneID: 71326; MW: 34.28 kDa).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: TREML1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:2000
  • Western Blot 0.3 - 1 ug/ml
• Application Notes: WB: Approx. 30 kDa band observed in human bone marrow lysates (calculated MW of 32.7 kDa band according to NP_835468.1).

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for TREML1/TLT-1 Antibody

• dJ238O23.3
• GLTL1825
• PRO3438
• TLT1
• TLT-1
• TLT1MGC119173
• TREML1
• trem-like transcript 1 protein
• triggering receptor expressed on myeloid cells-like 1
• Triggering receptor expressed on myeloid cells-like protein 1

Background

TREML1 is located in a gene cluster on chromosome 6 with the single Ig variable (IgV) domain activating receptors TREM1(MIM 605085) and TREM2 (MIM 605086), but it has distinct structural and functional properties. TREML1 enhances calciumsignaling in an SHP2 (PTPN11; MIM 176876)-dependent manner (Allcock et al., 2003 (PubMed 12645956); Barrow et al.,2004 (PubMed 15128762)).(supplied by OMIM)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TREML1/TLT-1 Antibody (NBP1-45208)(1)

Publication using NBP1-45208

• Nurden AT, Nurden P, Bermejo E et al. Phenotypic heterogeneity in the Gray platelet syndrome extends to the expression of TREM family member, TLT-1. Thromb Haemost 2008-07-01 [PMID: 18612537]

Bioinformatics

• Gene Symbol: TREML1
• Entrez:
  • 340205(Human)
• Uniprot:
  • NP_835468.1(Human)