Transglutaminase 3/TGM3 Antibody [Alexa Fluor™ Plus 488]

• Reactivity: Hu
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor Plus 488

Transglutaminase 3/TGM3 Antibody [Alexa Fluor™ Plus 488] Summary

• Specificity: Detects human Transglutaminase 3/TGM3 in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Transglutaminase 3/TGM3 Antibody [Alexa Fluor™ Plus 488]

• EC 2.3.2.13
• MGC126250
• protein-glutamine gamma-glutamyltransferase E
• TG(E)
• TG3
• TGase E
• TGase-3
• TgaseE
• TGEMGC126249
• TGM3
• transglutaminase 3 (E polypeptide, protein-glutamine-gamma-glutamyltransferase)
• Transglutaminase 3
• Transglutaminase E
• transglutaminase-3

Background

Transglutaminase 3 (TG3), also known as epidermal Transglutaminase (Tgase E), belongs to the family of Transglutaminase enzymes that catalyze the posttranslational modification of proteins via calcium dependent cross-linking reactions (1-3). TG3 is involved in the formation of the cornified envelope in skin keratinocytes (4). It functions to cross-link structural proteins during epidermal terminal differentiation. TG3 has been implicated as the dominant autoantigen in dermatitis herpetiformis (5). TG3 activation requires proteolysis of the 77 kDa zymogen into two fragments of approximately 50 and 27 kDa to form the active enzyme (1).

1. Kim, I.G. et al. (1993) J. Biol. Chem. 268:12682.
2. Griffin, M. et al. (2002) Biochem. J. 368:377.
3. Lorand, L. and R.M. Graham (2003) Nat. Rev. Mol. Cell Biol. 4:140.
4. Eckert, R.L. et al. (2005) J. Invest. Dermatol. 124:481.
5. Sardy, M. et al. (2002) J. Exp. Med. 195:747.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.