TRAF-4 Antibody (433709) [DyLight 350]

• Reactivity: Hu
• Applications: WB
• Clone: 433709
• Clonality: Monoclonal
• Host: Rat
• Conjugate: DyLight 350

TRAF-4 Antibody (433709) [DyLight 350] Summary

• Immunogen: E. coli-derived recombinant human TRAF-4
  Met1-Ser470
  Accession # Q9BUZ4
• Specificity: Detects endogenous human TRAF-4. In Western blots, this antibody does not cross-react with rhTRAF-1, -2, -3, -5, or -6 in Western blots.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Gene: TRAF4
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for TRAF-4 Antibody (433709) [DyLight 350]

• CART1
• CART1RING finger protein 83
• Cysteine-rich domain associated with RING and Traf domains protein 1
• Metastatic lymph node gene 62 protein
• MLN 62
• MLN62
• MLN62cysteine-rich domain associated with ring and TRAF domain
• RNF83malignant 62
• TNF receptor-associated factor 4
• TRAF4
• TRAF-4
• tumor necrosis receptor-associated factor 4A

Background

The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (reviewed in Chung et al, 2002). TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TRAF4