TOX3 Antibody

• Reactivity: Hu, Mu, Rt
• Applications: ELISA
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

TOX3 Antibody Summary

• Description: Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.
• Immunogen: Peptide with sequence AGDPASLDFAQC corresponding to N-Terminus according to NP_001073899.1.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: TOX3
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:128000
• Application Notes: WB: Preliminary experiments gave an approx. 100 kDa band in human brain (cerebellum) lysates after 0.2 ug/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the band we observe given the calculated size of 64.7 kDa band according to NP_001073899.1 The 100 kDa band was successfully blocked by incubation with the immunizing peptide.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for TOX3 Antibody

• CAG trinucleotide repeat-containing gene F9 protein
• CAGF9trinucleotide repeat containing 9
• TNRC9
• TOX high mobility group box family member 3
• Trinucleotide repeat-containing gene 9 protein

Background

The protein encoded by the TOX3 gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TOX3 Antibody (NBP1-00247)(1)

Publication using NBP1-00247

• Easton DF et al. Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 2007-06-28 [PMID: 17529967]

Bioinformatics

• Gene Symbol: TOX3
• Entrez:
  • 27324(Human)
  • 244579(Mouse)
  • 291908(Rat)
• Uniprot:
  • NP_001073899.1(Human)