Reactivity | HuSpecies Glossary |
Applications | WB, Flow |
Clone | TOX3/1124 |
Clonality | Monoclonal |
Host | Mouse |
Conjugate | DyLight 680 |
Immunogen | Recombinant fragment (139 Amino acid residues around aa 200-400) of human TOX3 protein |
Localization | Cytoplasmic & Nuclear |
Specificity | It recognizes a 63kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons through interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression through the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts. |
Isotype | IgG1 Kappa |
Clonality | Monoclonal |
Host | Mouse |
Gene | TOX3 |
Purity | Protein A or G purified |
Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
Dilutions |
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Application Notes | Optimal dilution of this antibody should be experimentally determined. |
Storage | Store at 4C in the dark. |
Buffer | 50mM Sodium Borate |
Preservative | 0.05% Sodium Azide |
Purity | Protein A or G purified |
Secondary Antibodies |
Isotype Controls |
Alexa Fluor 350 | NBP2-47749AF350 | |
Alexa Fluor 405 | NBP2-47749AF405 | |
Alexa Fluor 488 | NBP2-47749AF488 | |
Alexa Fluor 532 | NBP2-47749AF532 | |
Alexa Fluor 594 | NBP2-47749AF594 | |
Alexa Fluor 647 | NBP2-47749AF647 | |
Alexa Fluor 700 | NBP2-47749AF700 | |
Alexa Fluor 750 | NBP2-47749AF750 | |
Allophycocyanin | NBP2-47749APC | |
Biotin | NBP2-47749B | |
DyLight 350 | NBP2-47749UV | |
DyLight 405 | NBP2-47749V | |
DyLight 488 | NBP2-47749G | |
DyLight 550 | NBP2-47749R | |
DyLight 594 | NBP2-47749DL594 | |
DyLight 650 | NBP2-47749C | |
DyLight 680 | NBP2-47749FR | |
DyLight 755 | NBP2-47749IR | |
FITC | NBP2-47749F | |
HRP | NBP2-47749H | |
Janelia Fluor 549 | NBP2-47749JF549 | |
Janelia Fluor 646 | NBP2-47749JF646 | |
PE | NBP2-47749PE | |
PerCP | NBP2-47749PCP |
Diseases for TOX3 Antibody (NBP2-47749FR)Discover more about diseases related to TOX3 Antibody (NBP2-47749FR).
| Pathways for TOX3 Antibody (NBP2-47749FR)View related products by pathway.
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PTMs for TOX3 Antibody (NBP2-47749FR)Learn more about PTMs related to TOX3 Antibody (NBP2-47749FR).
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Gene Symbol | TOX3 |