TLK2 Antibody (OTI2D10) [Biotin]

• Reactivity: Hu, Mu, Rt
• Applications: IHC
• Clone: OTI2D10
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Biotin

TLK2 Antibody (OTI2D10) [Biotin] Summary

• Immunogen: Recombinant protein fragment corresponding to amino acids 1-296 of human TLK2 (NP_006843) produced in E.coli.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: TLK2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Mouse-On-Mouse blocking reagent may be needed for IHC and ICC experiments to reduce high background signal. You can find these reagents under catalog numbers PK-2200-NB and MP-2400-NB. Please contact Technical Support if you have any questions.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Immunogen affinity purified

Alternate Names for TLK2 Antibody (OTI2D10) [Biotin]

• EC 2.7.11
• EC 2.7.11.1
• MGC44450
• PKU-ALPHA
• serine/threonine-protein kinase tousled-like 2
• tousled-like kinase 2serine/threonine kinase

Background

TLK2 (Tousled-like kinase 2) is a nuclear serine/threonine kinase. It is cell cycle checkpoint and ATM-pathway dependent, with maximal activity in S-phase. It is rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. TLK2 is potentially involved in the regulation of chromatin assembly during DNA replication.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TLK2