TINAGL1 Antibody (812417) [Alexa Fluor® 594]

• Reactivity: Hu
• Applications: WB
• Clone: 812417
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 594

TINAGL1 Antibody (812417) [Alexa Fluor® 594] Summary

• Immunogen: Chinese hamster ovary cell line CHO-derived recombinant human TINAGL1
  Ala22-Met464
  Accession # Q9GZM7
• Specificity: Detects human TINAGL1 in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human TIN-Ag is observed.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TINAGL1 Antibody (812417) [Alexa Fluor® 594]

• androgen-regulated gene 1
• ARG1
• GIS5
• Glucocorticoid-inducible protein 5
• LCN7
• LIECG3
• lipocalin 7
• OLRG2
• OLRG-2
• Oxidized LDL-responsive gene 2 protein
• oxidized-LDL responsive gene 2
• P3ECSL
• TIN Ag-related protein
• TINAGL
• TINAGL1
• TINAG-like 1
• TINAGRP
• TIN-ag-RP
• tubulointerstitial nephritis antigen-like 1
• tubulointerstitial nephritis antigen-like
• Tubulointerstitial nephritis antigen-related protein

Background

TINAGL1 (Tubulointerstitial nephritis antigen-like 1; also TIN-ag-RP, AZ-1 and LCN7) is a 54-57 kDa glycoprotein member of the peptidase C1 family of molecules. It is secreted by renal tubule epithelium, zona glomerulosa cells, vascular smooth muscle and striated muscle cells. TINAGL1 may play a role in the spatial and temporal development of the steroid component of the adrenal, in part by suppressing the expression of CYP11B1. Human TINAGL1 is synthesized as a 467 amino acid (aa) precursor. It contains a 21 aa signal sequence and a 446 aa mature region (aa 22-467). Within the mature region is an SMB (somatomedin B) domain (aa 50-98), one vWFC domain (aa 105-140), and a nonenzymatic peptidase C1A region (aa 204-455). There are multiple potential isoform variants. One contains an alternative start site at Met106, another shows a deletion of aa 126-156, and a third possesses a 60 aa substitution for aa 1-194, coupled to a 38 aa insertion after Gly286, and a 16 aa substitution for aa 365-467. Undefined forms of 40-42 kDa and 22 kDa  have been noted in TINAGL1-transfected cell supernatant subjected to SDS-PAGE. Over aa 22‑464, human TINAGL1 shares 90% aa identity with mouse TINAGL1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.