TIMP-4 Antibody (SB30c)

Images

 
Western Blot: TIMP-4 Antibody (SB30c) [NBP1-28619] - 2 ug Mouse Anti-Human TIMP-4- on pancreatic cancer cell lysate with Goat Anti-Mouse IgG2a, human adsorbed-HRP
Immunocytochemistry/ Immunofluorescence: TIMP-4 Antibody (SB30c) [NBP1-28619] - 5 ug/mL Mouse Anti-Human TIMP-4- was stained on cold methanol fixed human pancraetic carcinoma cells with DAPI and Goat Anti-Mouse Ig, ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-Fr
Clone
SB30c
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
0.5 mg/ml

TIMP-4 Antibody (SB30c) Summary

Immunogen
Recombinant TIMP-4
Specificity
Human TIMP-4
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
TIMP4
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 5 ug/ml
Theoretical MW
25.5 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
0.1M BBS (pH 8.2)
Preservative
No Preservative
Concentration
0.5 mg/ml
Purity
Protein A or G purified

Alternate Names for TIMP-4 Antibody (SB30c)

  • metalloproteinase inhibitor 4
  • TIMP metallopeptidase inhibitor 4
  • TIMP4
  • TIMP-4
  • tissue inhibitor of metalloproteinase 4
  • Tissue inhibitor of metalloproteinases 4

Background

Tissue inhibitors of matrix metalloproteinases (TIMPs) constitute a family of secreted multifunctional proteins which are classified based on structural similarity to each other as well as their ability to inhibit matrix metalloproteinases (MMPs). TIMPs therefore play a critical role in ECM homeostasis but have also been shown to have erythroid-potentiating and cell growth-promoting activities. TIMP-4 (approx. 23kDa), unlike TIMP-1, TIMP-2 and TIMP-3, shows restricted localization to cardiac, neural, breast and muscle tissue. Cardiospecific TIMP-4 seems to play a significant role in regulating the normal cell phenotype since reduced levels elicit cellular transformation. It has been shown to be an inhibitor of MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9 with a preference for MMP-2 and MMP-7. (1-9)

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Additional TIMP-4 Products

Bioinformatics Tool for TIMP-4 Antibody (NBP1-28619)

Discover related pathways, diseases and genes to TIMP-4 Antibody (NBP1-28619). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for TIMP-4 Antibody (NBP1-28619)

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PTMs for TIMP-4 Antibody (NBP1-28619)

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Bioinformatics

Gene Symbol TIMP4
Entrez
Uniprot