TIMP-4 Products

Antibodies
TIMP-4 Antibody (153934) [Unc ...
TIMP-4 Antibody (153934) [Unconjug...
MAB974
Species: Hu
Applications: WB, IHC, ELISA(Cap)
Host: Mouse Monoclonal
TIMP-4 Antibody [Unconjugated ...
TIMP-4 Antibody [Unconjugated]
AF974
Species: Hu, Mu
Applications: WB
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
ELISA Kits
TIMP-4 ELISA Kit [Biotin]
TIMP-4 ELISA Kit [Biotin]
KA1768
Species: Hu
Lysates
TIMP-4 Overexpression Lysate ...
TIMP-4 Overexpression Lysate (Dena...
H00007079-T01
Species: Hu
Applications: WB
TIMP-4 Overexpression Lysate ...
TIMP-4 Overexpression Lysate (Native)
NBL1-16927
Applications: WB
Proteins
TIMP-4 Recombinant Protein
TIMP-4 Recombinant Protein
NBP2-52379
Species: Hu
Applications: PAGE
RNAi
TIMP-4 RNAi
TIMP-4 RNAi
H00007079-R01
Species: Hu

Description

The tissue inhibitors of metalloproteinases (TIMPs) are naturally occurring proteins that specifically inhibit matrix metalloproteinases and regulate extracellular matrix turnover and tissue remodeling by forming tight binding inhibitory complexes with the MMPs. Thus, TIMPs maintain the balance between matrix destruction and formation. An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. The TIMP proteins share several structural features including six loops held in place by six disulfide bonds arranged in three knot-like structures. These proteins also contain twelve cysteine residues in conserved regions of the molecule that form six disulfide bonds, essential for the formation of native conformations, and the N terminal region that is necessary for inhibitory activities. The N terminus of each TIMP contains a consensus sequence (VIRAK) and each TIMP is translated with a 29 amino acid leader sequence that is cleaved off to produce the mature protein. The C terminal regions are divergent, which enhances the selectivity of inhibition and binding efficiency. Although the TIMP proteins share high homology, they may either be secreted extracellularly in soluble form (TIMP1, TIMP2 and TIMP4) or bind to extracellular matrix components (TIMP3). The MMPs and TIMPs can be divided into two groups with respect to gene expression: the majority exhibit inducible expression and a small number are produced constitutively or are expressed at very low levels and are not inducible. Among agents that induce MMP and TIMP production are the inflammatory cytokines TNF alpha and IL1 beta. A marked cell type specificity is a hallmark of both MMP and TIMP gene expression (i.e. a limited number of cell types can be induced to make these proteins). Tissue Inhibitor of Metalloproteinases 4 (TIMP4) was identified by molecular cloning. TIMP4 shows 37 % amino acid identity with TIMP1 and 51 % homology with TIMP2 and TIMP3. TIMP4 is secreted extracellularly, predominantly in heart and brain tissue. It may function in a tissue specific fashion in extracellular matrix (ECM) homeostasis. TIMP4 has a strong inhibitory effect on the invasion of human breast cancer cells across reconstituted basement membranes suggesting that TIMP4 may have an important role in inhibiting primary tumor growth and progression. The human TIMP4 gene has the chromosomal location of 3p25.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 7079
Alternate Names
  • metalloproteinase inhibitor 4
  • TIMP-4
  • Tissue inhibitor of metalloproteinases 4
  • tissue inhibitor of metalloproteinase 4
  • TIMP metallopeptidase inhibitor 4

Research Areas for TIMP-4

Find related products by research area and learn more about each of the different research areas below.

Angiogenesis
Cancer
Cellular Markers
Hypoxia

PTMs for TIMP-4

Learn more about PTMs related to TIMP-4.

Methylation
Sulphation
Phosphorylation
Oxidation
Dephosphorylation
Acylation

Bioinformatics Tool for TIMP-4

Discover related pathways, diseases and genes to TIMP-4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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