TIMP-4 Products

TIMP-4 Antibody (153934) [Unc ...
TIMP-4 Antibody (153934) [Unconjug...
Species: Hu
Applications: WB, IHC, ELISA(Cap)
Host: Mouse Monoclonal
Formulation Catalog # Availability Price  
TIMP-4 Antibody [Unconjugated ...
TIMP-4 Antibody [Unconjugated]
Species: Hu, Mu
Applications: WB, ELISA
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Formulation Catalog # Availability Price  
Human TIMP-4 Quantikine ELISA ...
Human TIMP-4 Quantikine ELISA Kit
Species: Hu
Applications: ELISA
Human TIMP-4 DuoSet ELISA, 15 ...
Human TIMP-4 DuoSet ELISA, 15 Plate
Species: Hu
Applications: ELISA
Mouse TIMP-4 DuoSet ELISA, 5 ...
Mouse TIMP-4 DuoSet ELISA, 5 Plate
Species: Mu
Applications: ELISA
TIMP-4 Overexpression Lysate
TIMP-4 Overexpression Lysate
Species: Hu
Applications: WB
Recombinant Human TIMP-4 (Sf ...
Recombinant Human TIMP-4 (Sf 21-ex...
Species: Hu
Applications: Inhibition Activity
Formulation Catalog # Availability Price  
Recombinant Mouse TIMP-4 Prot ...
Recombinant Mouse TIMP-4 Protein, CF
Species: Mu
Applications: Enzyme Activity
Formulation Catalog # Availability Price  


The tissue inhibitors of metalloproteinases (TIMPs) are naturally occurring proteins that specifically inhibit matrix metalloproteinases and regulate extracellular matrix turnover and tissue remodeling by forming tight binding inhibitory complexes with the MMPs. Thus, TIMPs maintain the balance between matrix destruction and formation. An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. The TIMP proteins share several structural features including six loops held in place by six disulfide bonds arranged in three knot-like structures. These proteins also contain twelve cysteine residues in conserved regions of the molecule that form six disulfide bonds, essential for the formation of native conformations, and the N terminal region that is necessary for inhibitory activities. The N terminus of each TIMP contains a consensus sequence (VIRAK) and each TIMP is translated with a 29 amino acid leader sequence that is cleaved off to produce the mature protein. The C terminal regions are divergent, which enhances the selectivity of inhibition and binding efficiency. Although the TIMP proteins share high homology, they may either be secreted extracellularly in soluble form (TIMP1, TIMP2 and TIMP4) or bind to extracellular matrix components (TIMP3). The MMPs and TIMPs can be divided into two groups with respect to gene expression: the majority exhibit inducible expression and a small number are produced constitutively or are expressed at very low levels and are not inducible. Among agents that induce MMP and TIMP production are the inflammatory cytokines TNF alpha and IL1 beta. A marked cell type specificity is a hallmark of both MMP and TIMP gene expression (i.e. a limited number of cell types can be induced to make these proteins). Tissue Inhibitor of Metalloproteinases 4 (TIMP4) was identified by molecular cloning. TIMP4 shows 37 % amino acid identity with TIMP1 and 51 % homology with TIMP2 and TIMP3. TIMP4 is secreted extracellularly, predominantly in heart and brain tissue. It may function in a tissue specific fashion in extracellular matrix (ECM) homeostasis. TIMP4 has a strong inhibitory effect on the invasion of human breast cancer cells across reconstituted basement membranes suggesting that TIMP4 may have an important role in inhibiting primary tumor growth and progression. The human TIMP4 gene has the chromosomal location of 3p25.


Entrez Human
Uniprot Human
Product By Gene ID 7079
Alternate Names
  • metalloproteinase inhibitor 4
  • TIMP-4
  • Tissue inhibitor of metalloproteinases 4
  • tissue inhibitor of metalloproteinase 4
  • TIMP metallopeptidase inhibitor 4

Research Areas for TIMP-4

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Cellular Markers

PTMs for TIMP-4

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Bioinformatics Tool for TIMP-4

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