TIMP-3 Antibody (1D8)

Sandwich ELISA: TIMP-3 Antibody (1D8) [H00007078-M01] - Detection limit for recombinant GST tagged TIMP3 is 3 ng/ml as a capture antibody.

Product Discontinued

TIMP-3 Antibody (1D8) Summary

• Description: Quality control test: Antibody Reactive Against Recombinant Protein.
• Immunogen: TIMP3 (AAH14277, 112 a.a. ~ 211 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. KMYTGLCNFVERWDQLTLSQRKGLNYRYHLGCNCKIKSCYYLPCFVTSKNECLWTDMLSNFGYPGYQSKHYACIRQKGGYCSWYRGWAPPDKSIINATDP
• Specificity: TIMP3 - TIMP metallopeptidase inhibitor 3 (Sorsby fundus dystrophy, pseudoinflammatory) (1D8)
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: TIMP3
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Sandwich ELISA
• Application Notes: It has been used for ELISA.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: In 1x PBS, pH 7.4
• Preservative: No Preservative
• Purity: IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for TIMP-3 Antibody (1D8)

• HSMRK222
• K222
• K222TA2
• metalloproteinase inhibitor 3
• MIG-5 protein
• Protein MIG-5
• pseudoinflammatory)
• SFD
• TIMP metallopeptidase inhibitor 3
• TIMP3
• TIMP-3
• tissue inhibitor of metalloproteinase 3 (Sorsby fundus dystrophy
• Tissue inhibitor of metalloproteinases 3

Background

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are inhibitors of the matrix metalloproteinases, a group of peptidases involved in degradation of the extracellular matrix (ECM). Expression of this gene is induced in response to mitogenic stimulation and this netrin domain-containing protein is localized to the ECM. Mutations in this gene have been associated with the autosomal dominant disorder Sorsby's fundus dystrophy. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for TIMP-3 Antibody (H00007078-M01). (Showing 1 - 1 of 1 FAQ).

1. What I need is an antibody to human TIMP-3 that works in ELISA. It seems you offer 2 such products now, NBP1-67707 and H00007078-M01. The other criteria, which I can't discern from the product information, is that the Ab should be reactive with epitope(s) on the amino-terminal domain of this molecule, rather than the carboxyl terminus. Do you have this information and/or can you supply trial sizes of these or refund/replacement if unsuccessful?
   • The immunogen of antibody H00007078-M01 was a partial recombinant protein comprising amino acids at the C-terminal end of TIMP3. The amino acid range of the immunogen for NBP1-67707 is amino acids 100-150 of human TIMP3, P35625 (https://www.uniprot.org/uniprotkb/P35625/entry) This antibody binds to the TIMP3 region that mediates interaction with EFEMP1.

Bioinformatics

• Gene Symbol: TIMP3
• Entrez:
  • 7078(Human)
• Uniprot:
  • AAH14277(Human)