TIMP-2 Antibody (3A4)

Immunohistochemistry-Paraffin: TIMP-2 Antibody (3A4) [NBP2-26428] - Formalin fixed paraffin embedded human pancreas stained with TIMP2 antibody (NBP2-26428).

Immunohistochemistry-Paraffin: TIMP-2 Antibody (3A4) [NBP2-26428] - Analysis of TIMP2 formalin-fixed paraffin embedded human pancreatic tumor using NBP2-26428.

Product Discontinued

TIMP-2 Antibody (3A4) Summary

• Immunogen: BALB/C mice were injected with a synthetic peptide from the N-terminal region of human TIMP-2.
• Localization: Cytoplasmic
• Specificity: This antibody is specific to 21 kDa protein known as TIMP-2.
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: TIMP2
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry
  • Immunohistochemistry-Frozen 1:100
  • Immunohistochemistry-Paraffin 1:25-1:50

Reactivity Notes

Cow,Guinea Pig,Human,Mouse,Rabbit,Rat. Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: PBS (pH 7.4) and 0.2% BSA
• Preservative: 0.09% Sodium Azide
• Purity: Protein A or G purified

Alternate Names for TIMP-2 Antibody (3A4)

• CSC-21Ktissue inhibitor of metalloproteinase 2
• metalloproteinase inhibitor 2
• TIMP metallopeptidase inhibitor 2
• TIMP2
• TIMP-2
• Tissue inhibitor of metalloproteinases 2

Background

TIMP-1 and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family. TIMP are of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72 kDa Type IV collagenase (MMP-2) and active form of 92 kDa type IV collagenase (MMP-9). TIMP inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TIMP-2 Antibody (NBP2-26428)(1)

Publication using NBP2-26428

• Ayx IJV. Vergleichende Analyse des Angiogenese-und Metastasierungsverhaltens basaloid-squamoser Plattenepithelkarzinome gegenuber herkommlichen Plattenepithelkarzinomen des kopf-Hals-Bereichs. Thesis. 2014-01-01 (IHC-P, Human)

Bioinformatics

• Gene Symbol: TIMP2