Thymidylate Synthase Antibody

Images

 
Immunohistochemistry: Thymidylate Synthase Antibody [NBP1-36638] - IHC analysis of Thymidylate Synthase in human pancreatic tumor. Image courtesy of anonymous customer product review.
Immunohistochemistry-Paraffin: Thymidylate Synthase Antibody [NBP1-36638] Human Colon Carcinoma.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, IHC-P
Clonality
Polyclonal
Host
Rabbit

Order Details

Thymidylate Synthase Antibody Summary

Immunogen
A synthetic peptide derived from C-terminus of human TS protein
Specificity
This product is specific for TS
Clonality
Polyclonal
Host
Rabbit
Gene
TYMS
Purity
Immunogen affinity purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Conjugate
Unconjugated
Buffer
PBS (pH 7.6) and 1.0% BSA
Preservative
0.1% Sodium Azide
Purity
Immunogen affinity purified

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:100
Application Notes
This product is useful for Immunohistochemistry Paraffin. This product has a prediluted size available with catalog number NBP1-36642.
Reviewed Applications
Read 1 Review rated 4
using
NBP1-36638 in the following applications:

Reactivity Notes

This product is specific for Human.

Alternate Names for Thymidylate Synthase Antibody

  • EC 2.1.1.45
  • HsT422
  • MGC88736
  • thymidylate synthase
  • thymidylate synthetase
  • TMSTsase
  • TSase
  • TSHST422

Background

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Thymidylate Synthase Antibody (NBP1-36638) (0)

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Reviews for Thymidylate Synthase Antibody (NBP1-36638) (1) 41

Average Rating: 4
(Based on 1 reviews)
We have 1 review tested in 1 species: Human.
We have 1 review tested in 1 application: IHC-P.

Reviews using NBP1-36638:
Filter by Applications
IHC-P
(1)
All Applications
Filter by Species
Human
(1)
All Species
Images Ratings Applications Species Date Details
Immunohistochemistry-Paraffin Thymidylate Synthase NBP1-36638
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reviewed by:
Ranjuna Weeraskera
IHC-P Human 10/28/2011
View

Summary

ApplicationImmunohistochemistry-Paraffin
Sample TestedPancreatic tumor
SpeciesHuman

Blocking

Blocking DetailsBlocking Buffer: DAKO Protein block serum free, Blocking Time: 30 minutes, Blocking Temp: room temperature

Primary Anitbody

Dilution RatioPrimary Ab Dilution Ratio: 1:200, Primary Ab Incubation Dilution Buffer: Monet Blue, Incubation Time: 1hr, Incubation Temp: RT

Secondary Antibody

Secondary DescriptionSecondary Ab: MACH II polymer, Secondary Ab Dilution: Undiluted

Details

Detection NotesDAB, Pos Ctrl: Human Tonsil, Antigen Retrieval: Retrievit Target retrieval solution (Cat. BS-1006-00), 20 min @ 99 degrees
Fixation DetailsSample Preparation: paraffin embedded

Product General Protocols

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FAQs for Thymidylate Synthase Antibody (NBP1-36638) (0)

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Secondary Antibodies

 

Isotype Controls

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Contact Information

Product PDFs

Bioinformatics

Gene Symbol TYMS
Entrez
Uniprot

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