Thymidylate Synthase Antibody (TS106) [Alexa Fluor® 405]

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, ICC/IF, IHC, IHC-P
Clone
TS106
Clonality
Monoclonal
Host
Mouse
Conjugate
Alexa Fluor 405

Order Details

Thymidylate Synthase Antibody (TS106) [Alexa Fluor® 405] Summary

Immunogen
Recombinant full-length human Thymidylate Synthase protein.
Localization
Nuclear & Cytoplasmic
Marker
5-FU Resistance Marker
Specificity
It recognizes a protein of 36kDa, identified as Thymidylate Synthase (TS) (EC 2.1.1.45). TS converts deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate (dTMP), which is essential for DNA biosynthesis. TS is also a critical target for the fluoropyrimidines, an important group of antineoplastic drugs that are widely used in the treatment of solid tumors. Both 5-FU and fluorodeoxyuridine are converted in tumor cells to FdUMP which inactivates TS by formation of a ternary covalent complex in the presence of the folate cofactor 5,10-methylenetetrahydrofolate. Expression of TS protein is associated with response to 5-fluorouracil (5-FU) in human colorectal, gastric, head and neck, and breast carcinomas.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
TYMS
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Notes

Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for Thymidylate Synthase Antibody (TS106) [Alexa Fluor® 405]

  • EC 2.1.1.45
  • HsT422
  • MGC88736
  • thymidylate synthase
  • thymidylate synthetase
  • TMSTsase
  • TSase
  • TSHST422

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-34502AF350
Alexa Fluor 405 NBP2-34502AF405
Alexa Fluor 488 NBP2-34502AF488
Alexa Fluor 532 NBP2-34502AF532
Alexa Fluor 594 NBP2-34502AF594
Alexa Fluor 647 NBP2-34502AF647
Alexa Fluor 700 NBP2-34502AF700
Alexa Fluor 750 NBP2-34502AF750
Allophycocyanin NBP2-34502APC
Biotin NBP2-34502B
DyLight 350 NBP2-34502UV
DyLight 405 NBP2-34502V
DyLight 488 NBP2-34502G
DyLight 550 NBP2-34502R
DyLight 594 NBP2-34502DL594
DyLight 650 NBP2-34502C
DyLight 680 NBP2-34502FR
DyLight 755 NBP2-34502IR
FITC NBP2-34502F
HRP NBP2-34502H
Janelia Fluor 549 NBP2-34502JF549
Janelia Fluor 646 NBP2-34502JF646
PE NBP2-34502PE
PerCP NBP2-34502PCP

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Bioinformatics

Gene Symbol TYMS