Thrombopoietin R/Tpo R Recombinant Protein Summary
Thrombopoietin R/Tpo R (Human) GST-Tagged Recombinant Protein
Source: Wheat Germ (in vitro)
Amino Acid Sequence: MPSWALFMVTSCLLLAPQNLAQVSSQDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVKNVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHSASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCFTLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSPFWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQGPWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEEVEPSLLEILPKSSERTPLPLCSSQAQMDYRRLQPSCLGTMPLSVCPPMAESGSCCTTHIANHSYLPLSYWQQP
|Details of Functionality
This protein is not active and should not be used for experiments requiring activity.
Packaging, Storage & Formulations
Store at -80C. Avoid freeze-thaw cycles.
50 mM Tris-HCl, 10 mM reduced Glutathione, pH 8.0 in the elution buffer.
Useful in Western Blot and ELISA. This protein has not been tested for any functionality. This product may contain endotoxins and is not suitable for use with live cells.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for Thrombopoietin R/Tpo R Recombinant Protein
- CD110 antigen
- Myeloproliferative leukemia protein
- myeloproliferative leukemia virus oncogene
- Proto-oncogene c-Mpl
- Thrombopoietin R
- thrombopoietin receptor
In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq]
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed
for 3 months from date of receipt.
Customers Who Viewed This Item Also Viewed...
Applications: WB, ELISA, IA, S-ELISA
Applications: WB, ICC/IF, IHC, IHC-P, IP
Applications: WB, ELISA, Flow, ICC/IF, IHC, IHC-Fr, IHC-P, IP
Species: Hu, Mu, Rt
Applications: WB, Simple Western, ICC
Species: Hu, Rt, Ca, Pm
Applications: WB, Flow, ICC/IF, IHC, IHC-P
Species: Hu, Mu, Rt
Applications: WB, IP, ICC, ICFlow
Applications: IHC, IHC-P
Species: Hu, Mu
Applications: WB, Simple Western, Flow, IHC, CyTOF-ready
Applications: WB, ICC/IF, IHC, IHC-P
Applications: WB, ELISA
Applications: WB, ELISA, PA
Publications for Thrombopoietin R/Tpo R Recombinant Protein (H00004352-P01) (0)
There are no publications for Thrombopoietin R/Tpo R Recombinant Protein (H00004352-P01).
By submitting your publication information earn gift cards and discounts for future purchases.
Reviews for Thrombopoietin R/Tpo R Recombinant Protein (H00004352-P01) (0)
There are no reviews for Thrombopoietin R/Tpo R Recombinant Protein (H00004352-P01).
By submitting a review earn points towards our Rewards Program.
- 250 points for product review
- 500 additional points for an image with your product review
- Double points (500) if you are the first to review this product
- Double points (1000) if you are the first to review this product with an image
Product General Protocols
Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.
FAQs for Thrombopoietin R/Tpo R Recombinant Protein (H00004352-P01) (0)
Additional Thrombopoietin R/Tpo R Products
Related Products by Gene
Bioinformatics Tool for Thrombopoietin R/Tpo R Recombinant Protein (H00004352-P01)
Discover related pathways, diseases and genes to Thrombopoietin R/Tpo R Recombinant Protein (H00004352-P01). Need help?
Read the Bioinformatics Tool Guide
for instructions on using this tool.
Blogs on Thrombopoietin R/Tpo R