Thrombopoietin R/Tpo R Products

Antibodies
Thrombopoietin R/Tpo R Antibo ...
Thrombopoietin R/Tpo R Antibody
AF1016
Species: Hu
Applications: WB, Neut
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Thrombopoietin R/Tpo R Antibo ...
Thrombopoietin R/Tpo R Antibody (1...
FAB1016P
Species: Hu
Applications: Flow
Host: Mouse Monoclonal
Conjugate Catalog # Availability Size Price
Thrombopoietin R/Tpo R Antibo ...
Thrombopoietin R/Tpo R Antibody
AF1317
Species: Mu
Applications: WB
Host: Goat Polyclonal
Conjugate Catalog # Availability Size Price
Antibody Pairs
Thrombopoietin R/Tpo R Antibo ...
Thrombopoietin R/Tpo R Antibody Pair
H00004352-PW1
Species: Hu
Applications: WB, IP
Lysates
Thrombopoietin R/Tpo R Overex ...
Thrombopoietin R/Tpo R Overexpress...
H00004352-T01
Species: Hu
Applications: WB
Proteins
Thrombopoietin R/Tpo R Recomb ...
Thrombopoietin R/Tpo R Recombinant...
H00004352-P01
Species: Hu
Applications: WB, ELISA, PA
Thrombopoietin R/Tpo R Recomb ...
Thrombopoietin R/Tpo R Recombinant...
H00004352-G01
Species: Hu
RNAi
Thrombopoietin R/Tpo R RNAi
Thrombopoietin R/Tpo R RNAi
H00004352-R02
Species: Hu

Description

In 1990 an oncogene, v-mpl, was identified from the murine myeloproliferative leukemia virus that was capable of immortalizing bone marrow hematopoietic cells from different lineages. In 1992 the human homologue, named, c-mpl, was cloned. Sequence data revealed that c-mpl encoded a protein that was homologous with members of the hematopoietic receptor superfamily. Presence of anti-sense oligodeoxynucleotides of c-mpl inhibited megakaryocyte colony formation. The ligand for c-mpl, thrombopoietin, was cloned in 1994. Thrombopoietin was shown to be the major regulator of megakaryocytopoiesis and platelet formation. The protein encoded by the c-mpl gene, CD110, is a 635 amino acid transmembrane domain, with two extracellular cytokine receptor domains and two intracellular cytokine receptor box motifs. TPO-R deficient mice were severely thrombocytopenic, emphasizing the important role of CD110 and thrombopoietin in megakaryocyte and platelet formation. Upon binding of thrombopoietin CD110 is dimerized and the JAK family of non-receptor tyrosine kinases, as well as the STAT family, the MAPK family, the adaptor protein Shc and the receptors themselves become tyrosine phosphorylated. [provided by RefSeq]

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 4352
Alternate Names
  • CD110 antigen
  • Proto-oncogene c-Mpl
  • thrombopoietin receptor
  • Myeloproliferative leukemia protein
  • C-MPL
  • CD110
  • TPORMPLV
  • TPO-R
  • myeloproliferative leukemia virus oncogene

Bioinformatics Tool for Thrombopoietin R/Tpo R

Discover related pathways, diseases and genes to Thrombopoietin R/Tpo R. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.