TGF-beta RII Antibody (25508) [Phycoerythrin]

NS0 mouse myeloma cell line transfected with TGF-beta RII was stained with Mouse Anti-Human TGF-beta RII PE-conjugated Monoclonal Antibody (Catalog # FAB241P, filled histogram) or isotype control antibody (Catalog # IC002P, open histo-gram). View our protocol for Staining Membrane-associated Proteins.

• Reactivity: Hu
• Applications: Flow
• Clone: 25508
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Phycoerythrin

TGF-beta RII Antibody (25508) [Phycoerythrin] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human TGF-beta RII
  Ile24-Asp159
  Accession # P37173.2
• Specificity: This antibody has been validated by flow cytometry on TGF-beta RII-transfected cells only. In contrast to Catalog # FAB2411P, minimal staining of PBMC lymphocytes was observed with this antibody.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: TGFBR2
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TGF-beta RII Antibody (25508) [Phycoerythrin]

• AAT3
• EC 2.7.11
• EC 2.7.11.30
• FAA3
• HNPCC6
• LDS1B
• LDS2B
• MFS2
• RIIC
• TAAD2
• tbetaR-II
• TGF-beta receptor type II
• TGF-beta receptor type IIB
• TGF-beta receptor type-2
• TGF-beta RII
• TGF-beta type II receptor
• TGFbetaRII
• TGFbeta-RII
• TGFBR2
• TGF-bRII
• TGFR-2
• transforming growth factor beta receptor type IIC
• transforming growth factor, beta receptor II (70/80kDa) isoform 1
• transforming growth factor, beta receptor II (70/80kDa) isoform 2
• transforming growth factor, beta receptor II (70/80kDa)
• transforming growth factor, beta receptor II (70-80kD)
• Transforming growth factor-beta receptor type II

Background

TGF-beta RII is a membrane bound serine/threonine kinase. Upon ligand binding, TGF-beta RII interacts with TGF-beta RI to form the heteromeric signaling complex that transduces TGF-beta signals. A splice variant of the type II receptor, TGF-beta RIIb, containing a 25 amino acid residue insertion near the N-terminus of the mature protein has also been described.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TGF-beta RII Antibody (FAB241P)(10)

Publications using FAB241P

• Awad, K;Kakkola, L;Julkunen, I; High Glucose Increases Lactate and Induces the Transforming Growth Factor Beta-Smad 1/5 Atherogenic Pathway in Primary Human Macrophages Biomedicines 2024-07-16 [PMID: 39062148] (Flow Cytometry, Human)
• Oezel, L;Wohltmann, M;Gondorf, N;Wille, J;Güven, I;Windolf, J;Thelen, S;Jaekel, C;Grotheer, V; Dupuytren's Disease Is Mediated by Insufficient TGF-?1 Release and Degradation International journal of molecular sciences 2023-10-11 [PMID: 37894778] (Flow Cytometry, Human)
• M Toda, M Ueno, J Yamada, A Hiraga, K Asada, J Hamuro, C Sotozono, S Kinoshita Quiescent innate and adaptive immune responses maintain the long-term integrity of corneal endothelium reconstituted through allogeneic cell injection therapy Scientific Reports, 2022-10-27;12(1):18072. 2022-10-27 [PMID: 36302875] (Flow Cytometry, Human)
• Ying Fu, Zhiming Wang, Baichao Yu, Yuli Lin, Enyu Huang, Ronghua Liu et al. Intestinal CD11b+ B Cells Ameliorate Colitis by Secreting Immunoglobulin A Frontiers in Immunology 2021-11-03 [PMID: 34804004] (Flow Cytometry, Mouse, Transgenic Mouse)
• JM Sierra-Par, A Merino, M Eijken, H Leuvenink, R Ploeg, BK Møller, B Jespersen, CC Baan, MJ Hoogduijn Reparative effect of mesenchymal stromal cells on endothelial cells after hypoxic and inflammatory injury Stem Cell Res Ther, 2020-08-12;11(1):352. 2020-08-12 [PMID: 32787906] (Flow Cytometry, Immunophenotyping, Human)
• S Stephenson, MA Care, I Fan, A Zougman, DR Westhead, GM Doody, RM Tooze Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells J. Immunol., 2019-01-14;202(4):1287-1300. 2019-01-14 [PMID: 30642980] (Flow Cytometry, Human)
• MEGUMI MAEDA, YING CHEN, HIROAKI HAYASHI, NAOKO KUMAGAI-TAKEI, HIDENORI MATSUZAKI, SUNI LEE et al. Chronic exposure to asbestos enhances TGF-beta 1 production in the human adult T cell leukemia virus-immortalized T cell line MT-2 International Journal of Oncology 12/1/2014 [PMID: 25358858]
• Miller M, Petty C, Tompkins M, Fogle J CD4+CD25+ T regulatory cells activated during feline immunodeficiency virus infection convert T helper cells into functional suppressors through a membrane-bound TGFbeta / GARP-mediated mechanism. Virol J, 2014-01-18;11(0):7. 2014-01-18 [PMID: 24438223] (Flow Cytometry, Feline)
• Michelle M. Miller, Jonathan E. Fogle, Peter Ross, Mary B. Tompkins Feline glycoprotein A repetitions predominant anchors transforming growth factor beta on the surface of activated CD4(+)CD25(+) regulatory T cells and mediates AIDS lentivirus-induced T cell immunodeficiency AIDS Research and Human Retroviruses 4/1/2013 [PMID: 23373523]
• Lages CS, Suffia I, Velilla PA, Huang B, Warshaw G, Hildeman DA, Belkaid Y, Chougnet C Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. J. Immunol., 2008-08-01;181(3):1835-48. 2008-08-01 [PMID: 18641321] (Flow Cytometry, Human)

Bioinformatics

• Gene Symbol: TGFBR2
• Uniprot:
  • P37173.2()