TGF-beta RII Antibody (25508) [Allophycocyanin]

NS0 mouse myeloma cell line transfected with TGF-beta RII was stained with Mouse Anti-Human TGF-beta RII APC-conjugated Monoclonal Antibody (Catalog # FAB241A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.

• Reactivity: Hu
• Applications: Flow
• Clone: 25508
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Allophycocyanin

TGF-beta RII Antibody (25508) [Allophycocyanin] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human TGF-beta RII
  Ile24-Asp159
  Accession # P37173.2
• Specificity: This antibody has been validated by flow cytometry on TGF-beta RII-transfected cells only. In contrast to Catalog # FAB2411A, minimal staining of PBMC lymphocytes was observed with this antibody.
• Source: N/A
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: TGFBR2
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 10 uL/10^6 cells

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
• Buffer: Supplied in a saline solution containing BSA and Sodium Azide.
• Preservative: Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TGF-beta RII Antibody (25508) [Allophycocyanin]

• AAT3
• EC 2.7.11
• EC 2.7.11.30
• FAA3
• HNPCC6
• LDS1B
• LDS2B
• MFS2
• RIIC
• TAAD2
• tbetaR-II
• TGF-beta receptor type II
• TGF-beta receptor type IIB
• TGF-beta receptor type-2
• TGF-beta RII
• TGF-beta type II receptor
• TGFbetaRII
• TGFbeta-RII
• TGFBR2
• TGF-bRII
• TGFR-2
• transforming growth factor beta receptor type IIC
• transforming growth factor, beta receptor II (70/80kDa) isoform 1
• transforming growth factor, beta receptor II (70/80kDa) isoform 2
• transforming growth factor, beta receptor II (70/80kDa)
• transforming growth factor, beta receptor II (70-80kD)
• Transforming growth factor-beta receptor type II

Background

TGF-beta RII is a membrane bound serine/threonine kinase. Upon ligand binding, TGF-beta RII interacts with TGF-beta RI to form the heteromeric signaling complex that transduces TGF-beta signals. A splice variant of the type II receptor, TGF-beta RIIb, containing a 25 amino acid residue insertion near the N-terminus of the mature protein has also been described.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TGF-beta RII Antibody (FAB241A)(2)

Publications using FAB241A

• Stefan J. Erkeland, Christiaan J. Stavast, Joyce Schilperoord-Vermeulen, Giada Dal Collo, Harmen J.G. Van de Werken, Leticia G. Leon et al. The miR-200c/141-ZEB2-TGF beta axis is aberrant in human T-cell prolymphocytic leukemia Haematologica 2/18/2021 [PMID: 33596640]
• Joseph M McCune Lin28b Regulates Fetal Regulatory T Cell Differentiation through Modulation of TGF-? Signaling J. Immunol., 2016-10-28;0(0):. 2016-10-28 [PMID: 27793996] (Flow Cytometry, Human)

Bioinformatics

• Gene Symbol: TGFBR2
• Uniprot:
  • P37173.2()