TFPI-2 Antibody (243220)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IP
Clone
243220
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

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Catalog# & Formulation Size Price

TFPI-2 Antibody (243220) Summary

Immunogen
Mouse myeloma cell line NS0-derived recombinant human TFPI-2
Asp23-Phe235
Accession # P48307
Specificity
Detects human TFPI-2 in direct ELISAs and Western blots.
Source
N/A
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
TFPI2
Purity
Protein A or G purified from hybridoma culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1 ug/mL
  • Immunohistochemistry 8-25 ug/mL
  • Immunoprecipitation 25 ug/mL
Publications
Read Publication using
MAB2545 in the following applications:

  • ICC
    1 publication

Packaging, Storage & Formulations

Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
Preservative
No Preservative
Purity
Protein A or G purified from hybridoma culture supernatant
Reconstitution Instructions
Reconstitute at 0.5 mg/mL in sterile PBS.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TFPI-2 Antibody (243220)

  • Placental protein 5
  • PP5
  • PP5FLJ21164
  • REF-1
  • TFPI2
  • TFPI-2
  • TFPI-2REF1
  • tissue factor pathway inhibitor 2

Background

Human Tissue Factor Pathway Inhibitor 2 (TFPI-2), also known as placental protein 5 (PP5) and retinal pigment epithelial cell factor 1 (REF-1), is a secreted protein with an N-terminal acidic region, three Kunitz (K) domains (amino acids 36 to 86, 96 to 149 and 158 to 208) separated with by two linker regions, and a C-terminal basic region (1‑3). It is a Kunitz-type serine protease inhibitor secreted by all cells of the vasculature (endothelial cells, smooth muscle cells, and fibroblasts) into the extracellular matrix (ECM), where it plays a role in the regulation of urokinase/plasmin-mediated ECM turnover. Expression of TFPI-2 is down-regulated in several cancers, which may contribute to tumor progression in these cancers (4).

  1. Miyagi, Y. et al. (1994) J. Biochem. 116:939.
  2. Sprecher, C.A. et al. (1994) Proc. Natl. Acad. Sci. USA 91:3353.
  3. Tanaka, Y. et al. (2004) Invest. Ophthalmol. Vis. Sci. 45:245.
  4. Rollin, J. et al. (2005) Br, J. Cancer 92:775.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for TFPI-2 Antibody (MAB2545)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: ICC.


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ICC
(1)
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(1)
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Bioinformatics

Gene Symbol TFPI2
Entrez
Uniprot