TFCP2L1 Antibody [Alexa Fluor® 405]

• Reactivity: Hu
• Host: Goat
• Conjugate: Alexa Fluor 405

TFCP2L1 Antibody [Alexa Fluor® 405] Summary

• Specificity: Detects human TFCP2L1 in direct ELISAs and Western blots.
• Isotype: IgG
• Host: Goat

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TFCP2L1 Antibody [Alexa Fluor® 405]

• CRTR1
• CRTR1CRTR-1
• LBP9
• LBP-9
• LBP9CP2-related transcriptional repressor 1
• TFCP2L1
• transcription factor CP2-like 1
• transcription factor CP2-like protein 1
• Transcription factor LBP-9

Background

TFCP2L1 (Transcription factor CP2‑like protein # 1; also LBP‑9) is a 54 kDa (predicted) member of the CP2 subfamily, grh/CP2 family of proteins. It is expressed in placental synctiotrophoblast cells, and regulates the production of CYP11A1/P450scc. P450scc is a cholesterol cleavage enzyme that generates pregnenolone, a necessary intermediate in the formation of progesterone. TFCP2L1 both positively and negatively regulates P450scc synthesis through homodimerization and heterodimerization with LBP‑1b. Human TFCP2L1 is 479 amino acids (aa) in length. It contains a transcriptional repressor region (aa 100‑200) and a dimerization domain (aa 300‑479). There is one splice variant that shows a deletion of aa 400‑464. Human TFCP2L1 is 73% aa identical to human TFCP2, and 93% aa identical to mouse CRTR‑1, a closely related molecule that may not represent the actual mouse ortholog to TFCP2L1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.