TDO2 Antibody (OTI2A4)

Western Blot: TDO2 Antibody (OTI2A4) [NBP2-45995] -Analysis of overexpressedlysates(15ug per lane) from HEK293T cellstransfected with empty plasmid , lane1) , human TDO2 plasmid , lane 2),mouse TDO2 plasmid, lane 3) usinganti-TDO2 antibody (1:500). Figure B,Western blot analysis of the same samples asfigure A with anti-DDK antibody, 1:1000)

• Reactivity: Hu
• Applications: WB
• Clone: OTI2A4
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Concentration: 1 mg/ml

TDO2 Antibody (OTI2A4) Summary

• Immunogen: Full length human recombinant protein of human TDO2(NP_005642) produced in HEK293T cell.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: TDO2
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Western Blot 1:2000
• Theoretical MW: 47.7 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.3), 1.0% BSA and 50% Glycerol
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for TDO2 Antibody (OTI2A4)

• chky
• TDO
• TDO2
• TDOTO
• TO
• TPH2EC 1.13.11.11
• TRPO
• TRPOtryptophanase
• Tryptamin 2,3-dioxygenase
• tryptophan 2,3-dioxygenase
• Tryptophan Oxygenase
• Tryptophan Pyrrolase
• Tryptophanase

Background

Tryptophan 2,3-dioxygenase (EC 1.13.11.11) plays a role in catalyzing the first and rat-limiting step in the kynurenine pathway, the major pathway of tryptophan metabolism.[supplied by OMIM]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TDO2 Antibody (NBP2-45995)(3)

Publications using NBP2-45995

• Arnaud Jacquerie, Ann Hoeben, Daniëlle B. P. Eekers, Alida A. Postma, Maxime Vanmechelen, Frederik de Smet, Linda Ackermans, Monique Anten, Kim Severens, Axel zur Hausen, Martinus P. G. Broen, Jan Beckervordersandforth Prognostic relevance of high expression of kynurenine pathway markers in glioblastoma Scientific Reports 2024-06-28 [PMID: 38951170]
• Wu C, Spector S, Theodoropoulos G et al. Dual inhibition of IDO1/TDO2 enhances anti-tumor immunity in platinum-resistant non-small cell lung cancer Research Square 2022-10-27 [PMID: 37226257] (WB)
• Hao S, Huang G, Feng J et al. Non-NF2 mutations have a key effect on inhibitory immune checkpoints and tumor pathogenesis in skull base meningiomas J. Neurooncol. 2019-06-08 [PMID: 31177425]

Bioinformatics

• Gene Symbol: TDO2