TCF4 Antibody (6H5.3)

Product Discontinued

TCF4 Antibody (6H5.3) Summary

• Immunogen: Hybridoma produced by the fusion of splenocytes from BALB/c mice immunized with recombinant protein corresponding to amino acids 31-331 of the human TCF-4 protein.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: TCF4
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10 - 1:500
  • Immunoprecipitation 1:10 - 1:500
  • Western Blot 1:100-1:2000
• Application Notes: .

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: 0.7 M tris-glycine, pH 7.4, 0.105M NaCl, 30% glycerol
• Preservative: 0.035% Sodium Azide
• Purity: Protein A or G purified

Alternate Names for TCF4 Antibody (6H5.3)

• BHLHB19
• bHLHb19E2-2
• Class B basic helix-loop-helix protein 19
• Immunoglobulin transcription factor 2
• ITF-2
• ITF2PTHS
• MGC149724
• SEF-2
• SEF2-1
• SEF2-1A
• SEF2-1B
• SEF2MGC149723
• SL3-3 enhancer factor 2
• TCF-4
• transcription factor 4

Background

TCF 4 (T cell factor 4) is a member of the TCF/LEF (lymphoid enhancer factor) family of transcription factors. Members of this family along with catenin, are involved in mediating Wnt signaling by transactivating downstream genes. TCF 4 generates transcriptionally active complexes with catenin in colon carcinoma cells. Expression of TCF 4 is highest in the CNS and intestinal epithelium where Wnt signaling also plays an essential role in development. Aberrant TCF 4 transcription activity has been implicated in carcinogenesis of intestinal and mammary epithlia.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TCF4