TAZ/WWTR1 Antibody (672027) [Alexa Fluor® 700]

• Applications: WB, ICC/IF
• Clone: 672027
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

TAZ/WWTR1 Antibody (672027) [Alexa Fluor® 700] Summary

• Immunogen: E. coli-derived recombinant human TAZ/WWTR1
  Met267-Leu400
  Accession # Q9GZV5
• Specificity: Detects human TAZ/WWTR1 in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) YAP or rhYes is observed.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is provided under an agreement between Life Technologies Corporation and R&D Systems, Inc, and the manufacture, use, sale or import of this product is subject to one or more US patents and corresponding non-US equivalents, owned by Life Technologies Corporation and its affiliates. The purchase of this product conveys to the buyer the non-transferable right to use the purchased amount of the product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components (1) in manufacturing; (2) to provide a service, information, or data to an unaffiliated third party for payment; (3) for therapeutic, diagnostic or prophylactic purposes; (4) to resell, sell, or otherwise transfer this product or its components to any third party, or for any other commercial purpose. Life Technologies Corporation will not assert a claim against the buyer of the infringement of the above patents based on the manufacture, use or sale of a commercial product developed in research by the buyer in which this product or its components was employed, provided that neither this product nor any of its components was used in the manufacture of such product. For information on purchasing a license to this product for purposes other than research, contact Life Technologies Corporation, Cell Analysis Business Unit, Business Development, 29851 Willow Creek Road, Eugene, OR 97402, Tel: (541) 465-8300. Fax: (541) 335-0354.

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for TAZ/WWTR1 Antibody (672027) [Alexa Fluor® 700]

• FLJ27004
• FLJ45718
• TAZ
• TAZDKFZp586I1419
• transcriptional co-activator with PDZ-binding motif
• Transcriptional coactivator with PDZ-binding motif
• WW domain containing transcription regulator 1
• WW domain-containing transcription regulator protein 1
• WWTR1

Background

TAZ (Transcriptional co-Activatorr with PDZ-binding motif; also WWTR1) is a 50-55 kDa protein that is related to YAP65 TEF-1 interacting protein. It is a widely expressed transcriptional coactivator, and should not be confused with tafazzin/Taz, an enzyme associated with lipid metabolism. TAZ influences the nuclear transport of SMAD-2, -3 and -4, and in the nucleus, TAZ is known to interact with transcription factors such as TFF1, Pax8, NKX2-1 and TEADS, serving as a scaffold for transcriptional activation complexes. Human TAZ is 400 amino acids (aa) in length. It contains one WW domain (aa 124-157) that binds to PPXY motifs, a coiled-coil region (aa 225-259), and a PDZ binding domain (aa 394-400). There are at least four utilized phosphorylation sites. When phosphorylated on Ser89, TAZ preferentially bind to 14-3-3 proteins, promoting its retention in the cytoplasm. Over aa 267-400, human TAZ shares 88% aa identity with mouse TAZ.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

FAQs for TAZ/WWTR1 Antibody (FAB7210N). (Showing 1 - 1 of 1 FAQ).

1. I want to know which TAZ primary antibody is best produced for WB (human and mouse)!
   • I would recommend this TAZ antibody: NB110-58359. This is also comes in a sample size.

Bioinformatics

• Uniprot:
  • Q9GZV5(Human)