Western blot shows lysates of HepG2 human hepatocellular carcinoma cell line and Hep3B human hepatocellular carcinoma cell line. PVDF membrane was probed with 2 µg/mL of Mouse Anti-Human GFER/ALR Monoclonal Antibody ...read more
GFER/ALR was detected in immersion fixed paraffin-embedded sections of human liver using Mouse Anti-Human GFER/ALR Monoclonal Antibody (Catalog # MAB7940) at 15 µg/mL overnight at 4 °C. Before incubation with the ...read more
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Protein A or G purified from hybridoma culture supernatant
Sterile PBS to a final concentration of 0.5 mg/mL.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for GFER/ALR Antibody (829812)
ALRFAD-linked sulfhydryl oxidase ALR
Augmenter of liver regeneration
erv1-like growth factor
growth factor, augmenter of liver regeneration
growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
HERV1hepatic regenerative stimulation substance
truncated augmenter of liver regeneration
GFER, also known as Augmenter of Liver Regeneration (ALR) and Hepatopoietin, is an approximately 30 kDa mitochondrial sulfhydryl oxidase that plays a role in protein disulfide bond formation. Alternative splicing of human GFER generates a 15 kDa secreted isoform that lacks the 80 N-terminal amino acids. Within aa 82‑205, human GFER shares approximately 86% aa sequence identity with mouse and rat GFER. GFER protects hepatocytes from toxin-induced damage, promotes hepatic regeneration, and inhibits the metastasis of hepatocellular carcinoma. It also restricts the proliferation of pluripotent and hematopoietic stem cells and maintains mitochondrial integrity.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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