TAT Antibody (OTI3G6) [Janelia Fluor® 646]

• Reactivity: Hu, Mu, Rt
• Applications: WB
• Clone: OTI3G6
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 646

TAT Antibody (OTI3G6) [Janelia Fluor® 646] Summary

• Immunogen: Full length human recombiant protein of human TAT (NP_000344) produced in HEK293T cell.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: TAT
• Purity: >95%

Applications/Dilutions

• Dilutions:
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: >95%

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for TAT Antibody (OTI3G6) [Janelia Fluor® 646]

• EC 2.6.1.5
• L-tyrosine:2-oxoglutarate aminotransferase
• tyrosine aminotransferase
• tyrosine aminotransferase, cytosolic

Background

The transcriptional transactivator (Tat) is a key regulatory protein of HIV. It is expressed early after the virus integrates into the cell, and stimulates the elongation of RNA polymerase II. It binds onto a sequence known as the TAR, or transactivator response element, located at the end of the HIV genetic chain. There, the tat protein helps assemble new copies of HIV. The tat protein-TAR complex speeds up the rate of viral reproduction by about a thousand times. If it is not present, the transcription process frequently stops short, and few functional HIV particles are produced. Tat is an important potential target for antiretrovirals and vaccine development. Transcriptional regulator that acts by binding to the trans-activating responsive sequence (TAR) RNA element and activates transcription initiation and/or elongation from the LTR promoter.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TAT