TAT Products

Description

The transcriptional transactivator (Tat) is a key regulatory protein of HIV. It is expressed early after the virus integrates into the cell, and stimulates the elongation of RNA polymerase II. It binds onto a sequence known as the TAR, or transactivator response element, located at the end of the HIV genetic chain. There, the tat protein helps assemble new copies of HIV. The tat protein-TAR complex speeds up the rate of viral reproduction by about a thousand times. If it is not present, the transcription process frequently stops short, and few functional HIV particles are produced. Tat is an important potential target for antiretrovirals and vaccine development. Transcriptional regulator that acts by binding to the trans-activating responsive sequence (TAR) RNA element and activates transcription initiation and/or elongation from the LTR promoter.

Bioinformatics

Entrez	234724 Mouse 24813 Rat 6898 Human
Uniprot	AAH20707.1 Human NP_000344 Human P17735 Human
Product By Gene ID	6898
Alternate Names	EC 2.6.1.5 L-tyrosine:2-oxoglutarate aminotransferase tyrosine aminotransferase tyrosine aminotransferase, cytosolic

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Understanding Transcription with RNA Polymerase II RNA polymerase II is a large 12-subunit complex that synthesizes all mRNAs and several non-coding RNAs in eukaryotic cells. It is a DNA-dependent RNA polymerase enzyme that catalyzes transcription of DNA into RNA based on the four ribonucleoside triph...    Read more.

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