Tankyrase 1 Antibody (1A2)

Product Discontinued

Tankyrase 1 Antibody (1A2) Summary

• Description: Quality control test: Antibody Reactive Against Recombinant Protein.
• Immunogen: TNKS (NP_003738 1017 a.a. - 1124 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. TERKEGEVAGLDMNISQFLKSLGLEHLRDIFETEQITLDVLADMGHEELKEIGINAYGHRHKLIKGVERLLGGQQGTNPYLTFHCVNQGTILLDLAPEDKEYQSVEEE
• Localization: Cytoplasmic. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TRF1.
• Specificity: TNKS - tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
• Isotype: IgG2a Kappa
• Clonality: Monoclonal
• Host: Mouse
• Gene: TNKS
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Western Blot
• Application Notes: Antibody reactivity against recombinant protein for WB. It has been used for IHC-P and ELISA.

Packaging, Storage & Formulations

• Storage: Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.4)
• Preservative: No Preservative
• Purity: IgG purified

Notes

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Tankyrase 1 Antibody (1A2)

• EC 2.4.2.30
• PARP5A
• PARP-5a
• PARP5APARPL
• PARPL
• pART5
• Poly [ADP-ribose] polymerase 5A
• TANK1
• Tankyrase 1
• Tankyrase I
• tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
• tankyrase-1
• TIN1TANK1
• TINF1
• TINF1TNKS-1
• TNKS
• TNKS1TRF1-interacting ankyrin-related ADP-ribose polymerase

Background

Tankyrase is a protein with homology to ankyrins as well as to the catalytic domain of poly (adenosine diphosphate-ribose) polymerase (PARP). Tankyrase localizes to telomeres by binding to the telomeric repeat binding factor 1 (TRF1) through its ankyrin repeats. TRF1 is a negative regulator of telomere length maintenance. Tankyrase exhibits PARP activity functioning as acceptors for adenosine diphosphate (ADP)-ribosylation. Since ADP-ribosylation of TRF1 diminishes its ability to bind to telomeric DNA, this suggests that telomere function in human cells is regulated by poly (ADP)-ribosylation. Both the cell cycle and TRF1 may regulate the subcellular localization of tankyrase. During interphase tankyrase co-localizes with TRF1 to telomeres plus nuclear pore complexes whereas during mitosis tankyrase localizes around the pericentriolar matrix of mitotic chromosomes.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TNKS
• Entrez:
  • 8658(Human)
• OMIM:
  • 603303(Human)
• Uniprot:
  • NP_003738(Human)