TAB1 Antibody

Images

 
Western Blot: TAB1 Antibody [NBP2-20552] - Expression in transfected 293T cell line by MAP3K7IP1 polyclonal antibody. A: Non-transfected lysate. B: TAB1 transfected lysate. 12% SDS PAGE gel, diluted at 1:500.
Immunocytochemistry/ Immunofluorescence: TAB1 Antibody [NBP2-20552] - Confocal immunofluorescence analysis of paraformaldehyde-fixed HeLa, using TAB1 antibody (Green) at 1:500 dilution. Alpha-tubulin filaments are ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.26 mg/ml

Order Details

TAB1 Antibody Summary

Immunogen
Recombinant protein encompassing a sequence within the center region of human TAB1. The exact sequence is proprietary.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TAB1
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
  • Immunocytochemistry/Immunofluorescence 1:100-1:1000
Theoretical MW
55 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
Preservative
0.01% Thimerosal
Concentration
0.26 mg/ml
Purity
Immunogen affinity purified

Alternate Names for TAB1 Antibody

  • MAP3K7IP1
  • MAP3K7IP13'-Tab1
  • MGC57664
  • mitogen-activated protein kinase kinase kinase 7 interacting protein 1
  • Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
  • TAB1
  • TAK1-binding protein 1
  • TGF-beta activated kinase 1/MAP3K7 binding protein 1
  • TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
  • TGF-beta-activated kinase 1-binding protein 1
  • transforming growth factor beta-activated kinase-binding protein 1

Background

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol TAB1
Entrez
Uniprot