TAB1 Antibody (NBP1-76595)

Images

 
Western Blot: TAB1 Antibody [NBP1-76595] - 3T3 cell lysate with TAB1 antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.
Immunocytochemistry/ Immunofluorescence: TAB1 Antibody [NBP1-76595] - Immunofluorescence of TAB1 in 3T3 cells with TAB1 antibody at 2 ug/mL.
Immunocytochemistry/ Immunofluorescence: TAB1 Antibody [NBP1-76595] - K562 cells with TAB1 antibody at 1 ug/ml.

Product Details

Summary
Reactivity Hu, MuSpecies Glossary
Applications WB, ELISA, ICC/IF
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

TAB1 Antibody Summary

Immunogen
Antibody was raised against a synthetic peptide corresponding to 13 amino acids in the center of human TAB1. The immunogen is located within amino acids 220 - 270 of TAB1.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
TAB1
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 0.5-1 ug/ml
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 2 ug/ml
Application Notes
TAB1 antibody can be used for the detection of TAB1 by Western blot at 0.5 to 1 mg/ml.
Control Peptide
TAB1 Peptide (NBP1-76595PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for TAB1 Antibody

  • MAP3K7IP1
  • MAP3K7IP13'-Tab1
  • MGC57664
  • mitogen-activated protein kinase kinase kinase 7 interacting protein 1
  • Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
  • TAB1
  • TAK1-binding protein 1
  • TGF-beta activated kinase 1/MAP3K7 binding protein 1
  • TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
  • TGF-beta-activated kinase 1-binding protein 1
  • transforming growth factor beta-activated kinase-binding protein 1

Background

TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7, which is known to mediate various intracellular signaling pathways, such as those induced by TGF-beta and members of the Toll-IL-1R (TIR) superfamily, thus acting as an intermediate in both proliferative and innate and adaptive immune responses. This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals. It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF-beta, demonstrating how this protein can function as a mediator between TGF-beta receptors and TAK1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol TAB1
Entrez
Uniprot