TAB1 Antibody - BSA Free

Western Blot: TAB1 Antibody [NBP1-76595] - 3T3 cell lysate with TAB1 antibody at (A) 0.5, (B) 1, and (C) 2 ug/ml.

Immunocytochemistry/ Immunofluorescence: TAB1 Antibody - BSA Free [NBP1-76595] - Immunofluorescence of TAB1 in 3T3 cells with TAB1 antibody at 2 ug/mL.

Immunocytochemistry/ Immunofluorescence: TAB1 Antibody - BSA Free [NBP1-76595] - Immunocytochemistry of TAB1 in K562 cells with TAB1 antibody at 1 ug/mL.

• Reactivity: Hu, Mu
• Applications: WB, ELISA, ICC/IF
• Clonality: Polyclonal
• Host: Rabbit
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 1 mg/ml

TAB1 Antibody - BSA Free Summary

• Description: Novus Biologicals Rabbit TAB1 Antibody - BSA Free (NBP1-76595) is a polyclonal antibody validated for use in WB, ELISA and ICC/IF. Anti-TAB1 Antibody: Cited in 1 publication. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Antibody was raised against a synthetic peptide corresponding to 13 amino acids in the center of human TAB1. The immunogen is located within amino acids 220 - 270 of TAB1. Amino Acid Squence: ESTRRIGDYKVKY
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: TAB1
• Purity: Peptide affinity purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 1-2 ug/ml
  • Western Blot 0.5-2 ug/ml
• Control Peptide:

  TAB1 Peptide (NBP1-76595PEP)

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Concentration: 1 mg/ml
• Purity: Peptide affinity purified

Alternate Names for TAB1 Antibody - BSA Free

• MAP3K7IP1
• MAP3K7IP13'-Tab1
• MGC57664
• mitogen-activated protein kinase kinase kinase 7 interacting protein 1
• Mitogen-activated protein kinase kinase kinase 7-interacting protein 1
• TAB1
• TAK1-binding protein 1
• TGF-beta activated kinase 1/MAP3K7 binding protein 1
• TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
• TGF-beta-activated kinase 1-binding protein 1
• transforming growth factor beta-activated kinase-binding protein 1

Background

TAB1 was identified as a regulator of the MAP kinase kinase kinase TAK1/MAP3K7, which is known to mediate various intracellular signaling pathways, such as those induced by TGF-beta and members of the Toll-IL-1R (TIR) superfamily, thus acting as an intermediate in both proliferative and innate and adaptive immune responses. This protein, together with either TAB2 or TAB3, activates TAK1 kinase in response to upstream signals. It has been shown that the C-terminal portion of TAB1 is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF-beta, demonstrating how this protein can function as a mediator between TGF-beta receptors and TAK1.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for TAB1 Antibody (NBP1-76595)(1)

Publication using NBP1-76595

• Pierre-Marie Boutanquoi, Amira Sayed Khan, Lidia Cabeza, Lucas Jantzen, Thomas Gautier, Semen Yesylevskyy, Christophe Ramseyer, David Masson, Vincent Van Waes, Aziz Hichami, Naim Akhtar Khan A novel fatty acid analogue triggers CD36–GPR120 interaction and exerts anti-inflammatory action in endotoxemia Cellular and Molecular Life Sciences 2024-04-10 [PMID: 38598021]

Bioinformatics

• Gene Symbol: TAB1
• Uniprot:
  • NP_006107(Human)