Syntaxin-BP1 Antibody

Western Blot: Syntaxin-BP1 Antibody [NB100-41370] - Staining of Mouse Brain lysate (35 ug protein in RIPA buffer). Antibody at 0.3 ug/mL. Detected by chemiluminescence.

Western Blot: Syntaxin-BP1 Antibody [NB100-41370] - Staining of Human Cerebellum lysate (35 ug protein in RIPA buffer). Antibody at 0.1 ug/mL. Detected by chemiluminescence.

• Reactivity: Hu, Mu
• Applications: WB, ELISA
• Clonality: Polyclonal
• Host: Goat
• Conjugate: Unconjugated
• Concentration: 0.5 mg/ml

Syntaxin-BP1 Antibody Summary

• Immunogen: Peptide with sequence C-SRVSFEDQAPTME corresponding to C-Terminus according to NP_003156.1.
• Epitope: C-SRVSFEDQAPTME
• Specificity: This antibody is expected to recognize isoform a (NP_003156.1).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: STXBP1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:32000
  • Western Blot 0.1 - 0.3 ug/mL

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for Syntaxin-BP1 Antibody

• EIEE4
• FLJ37475
• hUNC18
• MUNC18-1
• NSEC1
• N-Sec1
• p67
• Protein unc-18 homolog 1
• Protein unc-18 homolog A
• rbSec1
• STXBP1
• syntaxin binding protein 1
• syntaxin-binding protein 1
• SyntaxinBP1
• Syntaxin-BP1
• UNC18
• Unc18-1
• UNC18A
• Unc-18A
• UNC18neuronal SEC1

Background

Munc18 may participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. It is essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Munc18 can interact with syntaxins 1, 2, and 3 but not syntaxin 4. It may play a role in determining the specificity of intracellular fusion reactions.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Syntaxin-BP1 Antibody (NB100-41370)(1)

Publication using NB100-41370

• Swanson DA, Steel JM, Valle D. Identification and characterization of the human ortholog of rat STXBP1, a protein implicated in vesicle trafficking and neurotransmitter release. Genomics 1998-03-15 [PMID: 9545644]

Bioinformatics

• Gene Symbol: STXBP1
• Entrez:
  • 6812(Human)
  • 20910(Mouse)
• Uniprot:
  • NP_003156.1(Human)