SUR1 Antibody

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Western Blot: SUR1 Antibody [NBP1-00138] - (0.5ug/ml) staining of Human Cer(35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

SUR1 Antibody Summary

Immunogen
Peptide with sequence C-EFDKPEKLLSRKD corresponding to C-Terminus according to NP_000343.2.
Epitope
C Terminus
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
ABCC8
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 0.5 - 1.5 ug/ml
  • Peptide ELISA Detection limit 1:8000
Application Notes
WB: Approx. 170 kDa band observed in human brain (cerebellum) lysates (calculated MW of 177 kDa band according to NP_000343.2). An additional band of unknown identity was also consistently observed at 23 kDa. This band was successfully blocked by incubation with the immunizing peptide.
Publications
Read Publication using NBP1-00138.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Mouse, Rat, Canine.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for SUR1 Antibody

  • ABC36
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 8
  • HHF1Sulfonylurea receptor 1
  • HI
  • PHHIHRINS
  • sulfonylurea receptor (hyperinsulinemia)
  • SUR1MRP8
  • SURATP-binding cassette transporter sub-family C member 8
  • TNDM2ATP-binding cassette sub-family C member 8

Background

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for SUR1 Antibody (NBP1-00138)(1)

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol ABCC8
Entrez
Uniprot