Sulfatase-2/SULF2 Antibody (2B4) [Alexa Fluor® 488]

• Reactivity: Hu, Mu
• Applications: WB
• Clone: 2B4
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 488

Sulfatase-2/SULF2 Antibody (2B4) [Alexa Fluor® 488] Summary

• Immunogen: Recombinant human Sulfatase-2/SULF2, used to immunize a SULF2-deficient mouse
  Accession # NP_940998
• Specificity: Detects human Sulfatase-2/SULF2 in direct ELISAs and Western blots.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Sulfatase-2/SULF2 Antibody (2B4) [Alexa Fluor® 488]

• DKFZp313E091
• EC 3.1.6
• EC 3.1.6.-
• EC 3.1.6.14
• extracellular sulfatase Sulf-2
• FLJ44488
• FLJ90554
• hSulf-2
• KIAA1247HSULF-2
• MGC126411
• SULF2
• SULF-2
• sulfatase 2
• Sulfatase2
• Sulfatase-2

Background

Sulfatase 2 (SULF2) is a 132 kDa calcium-binding glycoprotein that is one of two extracellular sulfatases (SULFs). SULFs degrade cell surface and extracellular matrix heparin sulfate proteoglycans, altering the binding and signaling of factors such as Wnts and FGFs. Dysregulation of SULF2 is implicated in carcinogenesis. A high molecular weight form (250 kDa) is presumed to be a covalent dimer, while smaller forms (60 kDa and 64 kDa) are produced by proteolytic cleavage. A splicing form, isoform b, differs only in non-coding regions. Within the region used as an immunogen, human SULF2 shares approximately 94% amino acid sequence identity with mouse and rat SULF2, while mouse and rat SULF2 share 98% amino acid sequence identity with each other.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.