Substance P Parameter Assay Kit



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Reactivity All-MultiSpecies Glossary
Applications ELISA

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Substance P Parameter Assay Kit Summary

The Parameter Substance P Immunoassay is a 3.5 hour competitive enzyme immunoassay designed to measure Substance P in cell culture supernates, serum, plasma, saliva, and urine. It contains a synthetically derived human Substance P peptide and has been shown to accurately quantitate this peptide. Results obtained using samples containing natural Substance P showed linear curves that were para...llel to the standard curves obtained using the Parameter kit standards. These results indicate that this kit can be used to determine relative mass values for natural Substance P.
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Measures Substance P levels in various samples
See PDF Datasheet for details
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details


Application Notes
No significant interference observed with available related molecules.
Read Publications using KGE007.

Packaging, Storage & Formulations

Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Substance P Parameter Assay Kit

  • neurokinin 1
  • neurokinin 2
  • neurokinin A
  • Neurokinin-1
  • neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)
  • neuropeptide gamma
  • neuropeptide K
  • NK2
  • NKA
  • NKNAneurokinin alpha
  • NPK
  • PPT
  • protachykinin-1
  • substance K
  • Substance P
  • TAC1
  • TAC2neuromedin L
  • tachykinin 2
  • tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2
  • tachykinin, precursor 1


Substance P (SP, Neurokinin-1), is member of the Tachykinin peptide family and binds primarily to the Neurokinin 1 Receptor (NK1R, Substance P receptor, Tachykinin receptor 1) and with low affinity to the NK2 and NK3 receptors. Substance P is processed from preproTachykinin a, b, g and d isoforms that also generate other Tachykinins Neuropeptide K, Neurokinin A, Neurokinin B, and Neuropeptide G. Substance P is produced in the central nervous system, primary sensory neurons (C-type fibers), and endocrine cells of the intestinal mucosa. It triggers pain signals in the spinal cord dorsal horn as well as hypotension, tachycardia, release of inflammatory mediators, and direct antimicrobial action.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to

Publications for Substance P (KGE007)(26)

We have publications tested in 4 confirmed species: Human, Mouse, Rat, Bovine.

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Showing Publications 1 - 10 of 26. Show All 26 Publications.
Publications using KGE007 Applications Species
A Yamada, Y Sato, T Horike, M Miyanaga, DH Wang Effects of a Forest Walk on Urinary Dityrosine and Hexanoyl-Lysine in Young People: A Pilot Study Int J Environ Res Public Health, 2020;17(14):. 2020 [PMID: 32664406] (Human) Human
HK Lee, KW Kim, JS Ryu, HJ Jeong, SM Lee, MK Kim Bilateral Effect of the Unilateral Corneal Nerve Cut on Both Ocular Surface and Lacrimal Gland Invest. Ophthalmol. Vis. Sci., 2019;60(1):430-441. 2019 [PMID: 30703211] (Mouse) Mouse
Q Li, X Wu, Y Yang, Y Zhang, F He, X Xu, Z Zhang, L Tao, C Luo Tachykinin NK1 receptor antagonist L-733,060 and substance P deletion exert neuroprotection through inhibiting oxidative stress and cell death after traumatic brain injury in mice Int. J. Biochem. Cell Biol., 2018;0(0):. 2018 [PMID: 30593954] (Mouse) Mouse
Y Xu, C Huang, H Deng, J Jia, Y Wu, J Yang, W Tu TRPA1 and substance P mediate stress induced duodenal lesions in water immersion restraint stress rat model Turk J Gastroenterol, 2018;29(6):692-700. 2018 [PMID: 30381276] (Mouse) Mouse
Li Z, Luo T, Ning X, Xiong C, Wu A Neurokinin-1 receptor antagonism improves postoperative neurocognitive disorder in mice. Neurosci Lett, 0;687(0):189-195. 0 [PMID: 30273701] (Mouse) Mouse
DSC Butler, I Ambite, K Nagy, C Cafaro, A Ahmed, A Nadeem, N Filenko, TH Tran, KE Andersson, B Wullt, M Puthia, C Svanborg Neuroepithelial control of mucosal inflammation in acute cystitis Sci Rep, 2018;8(1):11015. 2018 [PMID: 30030504] (Mouse) Mouse
L Lorente, MM Martín, A Pérez-Ceja, J Ferreres, J Solé-Violá, L Labarta, C Díaz, A Jiménez Sustained Low Serum Substance P Levels in Non-Surviving Septic Patients Int J Mol Sci, 2017;18(7):. 2017 [PMID: 28714876] (Human) Human
L Xiao, M Ding, A Fernandez, P Zhao, L Jin, X Li Curcumin alleviates lumbar radiculopathy by reducing neuroinflammation, oxidative stress and nociceptive factors Eur Cell Mater, 2017;33(0):279-293. 2017 [PMID: 28485773] (Mouse) Mouse
AJ Sandweiss, MI McIntosh, A Moutal, R Davidson-K, J Hu, AK Giri, T Yamamoto, VJ Hruby, R Khanna, TM Largent-Mi, TW Vanderah Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential Mol. Psychiatry, 2017;0(0):. 2017 [PMID: 28485408] (Rat) Rat
Y Okamura, S Mishima, JI Kashiwakur, T Sasaki-Sak, S Toyoshima, K Kuroda, S Saito, Y Tokuhashi, Y Okayama The dual regulation of substance P-mediated inflammation via human synovial mast cells in rheumatoid arthritis Allergol Int, 2017;0(0):. 2017 [PMID: 28366675] (Human) Human
Show All 26 Publications.

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Product General Protocols

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FAQs for Substance P (KGE007). (Showing 1 - 1 of 1 FAQs).

  1. wondering what the difference is between your quantikine and duo set elisas?
    • Usually the duosets do not have the entire kit such as plates and buffers, whereas the other kits are complete.

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