Substance P Parameter Assay Kit

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Product Details

Summary
Reactivity All-MultiSpecies Glossary
Applications ELISA
Conjugate
Biotin

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Substance P Parameter Assay Kit Summary

Background
The Parameter Substance P Immunoassay is a 3.5 hour competitive enzyme immunoassay designed to measure Substance P in cell culture supernates, serum, plasma, saliva, and urine. It contains a synthetically derived human Substance P peptide and has been shown to accurately quantitate this peptide. Results obtained using samples containing natural Substance P showed linear curves that were para...llel to the standard curves obtained using the Parameter kit standards. These results indicate that this kit can be used to determine relative mass values for natural Substance P.
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Specificity
Measures Substance P levels in various samples
Inter-Assay
See PDF Datasheet for details
Intra-Assay
See PDF Datasheet for details
Spike Recovery
See PDF Datasheet for details
Sample Volume
See PDF Datasheet for details

Applications/Dilutions

Dilutions
  • ELISA
Application Notes
No significant interference observed with available related molecules.
Publications
Read Publications using KGE007.

Packaging, Storage & Formulations

Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Substance P Parameter Assay Kit

  • neurokinin 1
  • neurokinin 2
  • neurokinin A
  • Neurokinin-1
  • neuromedin L, neurokinin alpha, neuropeptide K, neuropeptide gamma)
  • neuropeptide gamma
  • neuropeptide K
  • NK2
  • NKA
  • NKNAneurokinin alpha
  • NPK
  • PPT
  • protachykinin-1
  • substance K
  • Substance P
  • TAC1
  • TAC2neuromedin L
  • tachykinin 2
  • tachykinin, precursor 1 (substance K, substance P, neurokinin 1, neurokinin 2
  • tachykinin, precursor 1

Background

Substance P (SP, Neurokinin-1), is member of the Tachykinin peptide family and binds primarily to the Neurokinin 1 Receptor (NK1R, Substance P receptor, Tachykinin receptor 1) and with low affinity to the NK2 and NK3 receptors. Substance P is processed from preproTachykinin a, b, g and d isoforms that also generate other Tachykinins Neuropeptide K, Neurokinin A, Neurokinin B, and Neuropeptide G. Substance P is produced in the central nervous system, primary sensory neurons (C-type fibers), and endocrine cells of the intestinal mucosa. It triggers pain signals in the spinal cord dorsal horn as well as hypotension, tachycardia, release of inflammatory mediators, and direct antimicrobial action.

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⚠ WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Publications for Substance P (KGE007)(31)

We have publications tested in 5 confirmed species: Human, Mouse, Rat, Bovine, Rats.


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Human
(13)
Mouse
(12)
Rat
(4)
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(1)
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Showing Publications 1 - 10 of 31. Show All 31 Publications.
Publications using KGE007 Applications Species
JH Park, CH Lee, HD Ham, ES Choi, C Lee, S Lee Analgesic effects of a 5-HT3 receptor antagonist in an animal model of complex regional pain syndrome European review for medical and pharmacological sciences, 2021;25(22):7051-7057. 2021 [PMID: 34859869] (Rats) Rats
J Cheng, Z Xie, S Wang, S Wen, S Niu, C Shi, L Yu, X Xu Cough hypersensitivity in patients with metabolic syndrome: a clinical finding and its possible mechanisms BMC pulmonary medicine, 2021;21(1):284. 2021 [PMID: 34488706] (Human) Human
YC Liu, GH Yam, MT Lin, E Teo, SK Koh, L Deng, L Zhou, L Tong, JS Mehta Comparison of tear proteomic and neuromediator profiles changes between small incision lenticule extraction (SMILE) and femtosecond laser-assisted in-situ keratomileusis (LASIK) Journal of advanced research, 2021;29(0):67-81. 2021 [PMID: 33842006] (Human) Human
SE Lee, SJ Lee, SE Kim, K Kim, B Cho, K Roh, SC Kim Intravenous allogeneic umbilical cord blood-derived mesenchymal stem cell therapy in recessive dystrophic epidermolysis bullosa patients JCI Insight, 2021;6(2):. 2021 [PMID: 33491668] (Human) Human
X Zeng, C Xu, X Xu, Y Zhang, Y Huang, X Huo Elevated lead levels in relation to low serum neuropeptide Y and adverse behavioral effects in preschool children with e-waste exposure Chemosphere, 2020;269(0):129380. 2020 [PMID: 33383249] (Human) Human
A Yamada, Y Sato, T Horike, M Miyanaga, DH Wang Effects of a Forest Walk on Urinary Dityrosine and Hexanoyl-Lysine in Young People: A Pilot Study Int J Environ Res Public Health, 2020;17(14):. 2020 [PMID: 32664406] (Human) Human
HK Lee, KW Kim, JS Ryu, HJ Jeong, SM Lee, MK Kim Bilateral Effect of the Unilateral Corneal Nerve Cut on Both Ocular Surface and Lacrimal Gland Invest. Ophthalmol. Vis. Sci., 2019;60(1):430-441. 2019 [PMID: 30703211] (Mouse) Mouse
Q Li, X Wu, Y Yang, Y Zhang, F He, X Xu, Z Zhang, L Tao, C Luo Tachykinin NK1 receptor antagonist L-733,060 and substance P deletion exert neuroprotection through inhibiting oxidative stress and cell death after traumatic brain injury in mice Int. J. Biochem. Cell Biol., 2018;0(0):. 2018 [PMID: 30593954] (Mouse) Mouse
Y Xu, C Huang, H Deng, J Jia, Y Wu, J Yang, W Tu TRPA1 and substance P mediate stress induced duodenal lesions in water immersion restraint stress rat model Turk J Gastroenterol, 2018;29(6):692-700. 2018 [PMID: 30381276] (Mouse) Mouse
Li Z, Luo T, Ning X, Xiong C, Wu A Neurokinin-1 receptor antagonism improves postoperative neurocognitive disorder in mice. Neurosci Lett, 0;687(0):189-195. 0 [PMID: 30273701] (Mouse) Mouse
Show All 31 Publications.

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