STYK1 Antibody (484713) [Alexa Fluor™ Plus 488]

• Reactivity: Hu
• Clone: 484713
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 488

STYK1 Antibody (484713) [Alexa Fluor™ Plus 488] Summary

• Specificity: Detects human STYK1 in direct ELISAs.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for STYK1 Antibody (484713) [Alexa Fluor™ Plus 488]

• DKFZp761P1010
• EC 2.7.10.2
• NOK
• NOKProtein PK-unique
• serine/threonine/tyrosine kinase 1Novel oncogene with kinase domain
• STYK1
• SuRTK106
• tyrosine-protein kinase STYK1

Background

STYK1 (Ser/Thr/Tyr kinase 1; also NOK, or “novel oncogene with kinase-domain”) is a 50 kDa, distant member of the FGFR/PDGFR family of tyrosine kinases.  It appears to be intracellular, even though it contains a putative transmembrane segment.  Both MAPK and PI3K pathways are activated by STYK1 activity, and STYK1 is associated with oncogenesis.  Human STYK1 is 422 amino acids (aa) in length.  It contains 25 aa N-terminus, a 21 aa putative transmembrane segment, and a 396 aa C-terminus that contains a Tyr-kinase domain (aa 118-372).  Over aa 72-320, human STYK1 is 77% and 83% identical to mouse and canine STYK1, respectively.  

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.