STIM1 Antibody (705111) [Janelia Fluor® 646]

• Reactivity: Hu, Mu, Rt
• Applications: WB, KO
• Clone: 705111
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Janelia Fluor 646

STIM1 Antibody (705111) [Janelia Fluor® 646] Summary

• Immunogen: E. coli-derived recombinant human STIM1
  Leu23-Thr182
  Accession # Q13586
• Specificity: Detects human STIM1 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human STIM2 is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Mouse
• Gene: STIM1
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • Knockout Validated
  • Western Blot
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for STIM1 Antibody (705111) [Janelia Fluor® 646]

• GOK
• GOKD11S4896E
• STIM1
• stromal interaction molecule 1

Background

Stromal interaction molecule 1 plays a role in mediating Ca(2+) influx following depletion of intracellular Ca(2+) stores. It acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, it translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: STIM1